{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T19:03:37Z","timestamp":1783969417203,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T00:00:00Z","timestamp":1736985600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is scarce data on the prognostic value of frailty in patients with Takotsubo cardiomyopathy (TCM). This study aimed to assess the association between frailty and in\u2010hospital outcomes in patients with TCM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adult admissions with TCM were included using the 2016\u22122019 National Inpatient Sample database. The primary outcome was in\u2010hospital mortality and secondary outcomes included cardiogenic shock, in\u2010hospital cardiac arrest, stroke\/transient ischemic attack (TIA), length of hospital stay, and total charges. Frailty was assessed using the hospital frailty risk score (HFRS), and admissions were divided into two groups: low risk and intermediate\/high risk of frailty. Logistic regression was used to estimate odds ratios (OR) with their 95% confidence intervals (CI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 32\u2009360 patients were included; the median age was 67 (58\u221276) years and 90% were female. The median HFRS was 2.6 (1.1\u22125.3). In the adjusted models, in\u2010hospital mortality was significantly higher in the intermediate\/high risk of frailty group (OR 3.60, 95% CI 2.16\u22126.02) compared to the low\u2010risk group. Similarly, admissions with intermediate\/high risk of frailty had a significantly higher risk of cardiogenic shock (OR 3.66, 95% CI 2.77\u22124.80), in\u2010hospital cardiac arrest (OR 2.57, 95% CI 1.55\u22124.24), and stroke\/TIA (OR 5.68, 95% CI 3.51\u22129.20). There was a significantly higher hospital charges and length of hospital stay in the intermediate\/high\u2010risk group. In the restricted cubic spline regression models, the frailty score was nonlinearly associated with all outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results suggest that frailty is useful as a prognostic factor for in\u2010hospital events in patients with TCM.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.70054","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T10:44:02Z","timestamp":1737024242000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prognostic Value of Frailty in Patients With Takotsubo Cardiomyopathy"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5101-2832","authenticated-orcid":false,"given":"Carlos","family":"Diaz\u2010Arocutipa","sequence":"first","affiliation":[{"name":"Unidad de Revisiones Sistem\u00e1ticas y Meta\u2010an\u00e1lisis (URSIGET) Vicerrectorado de Investigaci\u00f3n, Universidad San Ignacio de Loyola Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian V.","family":"Hernandez","sequence":"additional","affiliation":[{"name":"Unidad de Revisiones Sistem\u00e1ticas y Meta\u2010an\u00e1lisis (URSIGET) Vicerrectorado de Investigaci\u00f3n, Universidad San Ignacio de Loyola Lima Peru"},{"name":"Health Outcomes, Policy, and Evidence Synthesis (HOPES) Group University of Connecticut School of Pharmacy Storrs Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy076"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.06.016"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-019-09843-9"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu197"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-20-0594"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30668-8"},{"key":"e_1_2_11_8_1","unstructured":"L.Sim T. Y.Chang K. K.Htin et al. \u201cModified Hospital Frailty Risk Score (mHFRS) as a Tool to Identify and Predict Outcomes for Hospitalised Older Adults at Risk of Frailty.\u201d"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11082193"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2020.00564"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.10.060"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2018.287318"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab468"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-018-0064-2"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad274"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.11.029"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.008251"},{"key":"e_1_2_11_18_1","article-title":"Frailty Scores and Their Utility in Older Patients With Cardiovascular Disease","volume":"16","author":"Ng Cheong Chung K. J.","year":"2021","journal-title":"Interventional Cardiology Review"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2301292"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.11124\/JBISRIR-2017-003382"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rec.2018.06.035"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.70054","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T12:40:02Z","timestamp":1750855202000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.70054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1002\/clc.70054"],"URL":"https:\/\/doi.org\/10.1002\/clc.70054","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-09-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70054"}}