{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T02:22:21Z","timestamp":1764210141620,"version":"3.41.2"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T00:00:00Z","timestamp":1736899200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Clinical trials support dronedarone use for atrial fibrillation (AF) following catheter ablation (CA); however, comparative data on health care resource utilization (HCRU) with other antiarrhythmic drugs are lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective analysis of Merative MarketScan databases (January 01, 2012\u2212March 31, 2020) comparatively assessed HCRU in US adults with AF who received dronedarone or sotalol post\u2010CA. Patients with \u2265\u200912\u2010months' pre\u2010CA data were followed from post\u2010CA index treatment to disenrollment, death, or study end. Sotalol\u2010treated patients were propensity score\u2010matched (1:1) with dronedarone\u2010treated patients. Events\/100 patient\u2010years (PY) were analyzed by univariate generalized\u2010linear model with Poisson distribution. Cumulative incidence was analyzed over 12 months by Kaplan\u2013Meier methods. Subgroup analyses were conducted by sex and patients new to dronedarone or sotalol during 12 months pre\u2010CA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Dronedarone and sotalol cohorts were successfully matched (<jats:italic>n<\/jats:italic>\u2009=\u20091600 each). Prevalence\/100\u2010PY for all\u2010cause, cardiovascular (CV)\u2010related, and atrial tachyarrhythmia (ATA)\/AF\u2013related HCRU was lower in dronedarone versus sotalol cohort (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Cumulative incidence for all\u2010cause, CV\u2010related, ATA\/AF\u2010related hospitalizations, and pacemaker implantation was lower in dronedarone versus sotalol cohort (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Incidence of all\u2010cause and CV\u2010related hospitalizations was lower in dronedarone versus sotalol cohorts in females (<jats:italic>n<\/jats:italic>\u2009=\u2009460) and males (<jats:italic>n<\/jats:italic>\u2009=\u20091115) (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) after rematching. Incidence of ATA\/AF\u2010related hospitalization was lower in males versus females receiving dronedarone. For patients new to dronedarone or sotalol (<jats:italic>n<\/jats:italic>\u2009=\u2009549), HCRU results were generally consistent with primary analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Post\u2010CA dronedarone, versus sotalol, lowered CV\u2010related HCRU in all\u2010comers with AF and in sex subgroups. Findings may contribute to clinical decision making post\u2010CA in patients with AF.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.70064","type":"journal-article","created":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T11:43:18Z","timestamp":1736941398000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Health Care Resource Utilization With Dronedarone Versus Sotalol Following Catheter Ablation in Adults With Atrial Fibrillation"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4848-4775","authenticated-orcid":false,"given":"Emily P.","family":"Zeitler","sequence":"first","affiliation":[{"name":"Department of Medicine Dartmouth\u2010Hitchcock Medical Center Lebanon New Hampshire USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dara","family":"Stein","sequence":"additional","affiliation":[{"name":"Real\u2010world Evidence Evidera London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7923-041X","authenticated-orcid":false,"given":"Ron","family":"Preblick","sequence":"additional","affiliation":[{"name":"Health Economics and Outcomes Research Sanofi, Bridgewater  New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9945-6491","authenticated-orcid":false,"given":"Shaum M.","family":"Kabadi","sequence":"additional","affiliation":[{"name":"Real\u2010world Evidence Sanofi, Bridgewater New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4402-6814","authenticated-orcid":false,"given":"David S.","family":"McKindley","sequence":"additional","affiliation":[{"name":"US Medical, Sanofi Bridgewater New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Rashkin","sequence":"additional","affiliation":[{"name":"US Medical, Sanofi Bridgewater New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"Huse","sequence":"additional","affiliation":[{"name":"Real\u2010world Evidence Evidera Cambridge Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Stamas","sequence":"additional","affiliation":[{"name":"Real\u2010world Evidence Evidera Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1458-8234","authenticated-orcid":false,"given":"Michael H.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Medicine Creighton University School of Medicine and CHI Health Omaha Nebraska USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,15]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2020-317656"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.11.010"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001052"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-022-14403-2"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61774-8"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2013.05.063"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.005119"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccep.2020.10.010"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hroo.2022.07.010"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737167.2022.2045955"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.110.958165"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/2047487314538855"},{"key":"e_1_2_12_14_1","doi-asserted-by":"crossref","unstructured":"J. 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