{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:12:51Z","timestamp":1791936771033,"version":"4.3.4"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T00:00:00Z","timestamp":1738800000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Finerenone, a nonsteroidal mineralocorticoid receptor antagonist, has emerged as a novel therapeutic option for the management of patients with diabetes, chronic kidney disease, or heart failure. We seek to summarize the evidence on the drug's effectiveness regarding cardiovascular (CV) outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a literature search of Pubmed, Cochrane CENTRAL, Embase, and <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link> from inception to September 2024. Trials exploring the effects of finerenone on CV outcomes were extracted and analyzed. The results of pooled analyses were presented as risk ratios (RRs) with 95% confidence intervals (CIs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of eight trials, incorporating 21\u2009200 patients, were included. The pooled analysis demonstrated a significant reduction in all\u2010cause death (RR 0.92, 95% CI: 0.85\u20130.99), major adverse CV events (RR 0.85, 95% CI: 0.81\u20130.90), heart failure\u2010related hospitalizations or unplanned hospital visits (RR 0.82, 95% CI: 0.76\u20130.87) with finerenone administration compared to control. Finerenone use was associated with a trend of reduced risk of CV death without reaching statistical significance (RR 0.90, 95% CI: 0.81\u20131.00). The risk of myocardial infarction (RR 0.91, 95% CI: 0.74\u20131.12), adverse events (RR 0.96, 95% CI: 0.89\u20131.03), adverse events leading to discontinuation (RR 1.06, 95% CI: 0.96\u20131.17) remained comparable across both groups. However, an increased risk of hyperkalemia (RR 2.07, 95% CI: 1.88\u20132.27) was observed with finerenone therapy compared to the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Finerenone administration was associated with improved CV outcomes in the CV\u2010renmetabolic conditions compared to the control group.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.70065","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T08:49:21Z","timestamp":1738831761000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Cardiovascular Efficacy and Safety of Finerenone: A Meta\u2010Analysis of Randomized Controlled Trials"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9872-8224","authenticated-orcid":false,"given":"Mushood","family":"Ahmed","sequence":"first","affiliation":[{"name":"Rawalpindi Medical University Rawalpindi 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