{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T03:35:17Z","timestamp":1778038517746,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T00:00:00Z","timestamp":1738627200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>CHA2DS2\u2010VASc is used to assess the risk of stroke in patients with atrial fibrillation (AF) and guide anticoagulant treatment decisions, but it has limitations in accurately predicting stroke risk in individual patients. The objective of this study is to conduct a cohort study by assessing preoperative levels of Gal\u20103 in paroxysmal AF patients, aiming to observe its correlation with the subsequent incidence of stroke events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This study enrolled 197 patients with nonvalvular paroxysmal AF. Blood samples were taken to test Gal\u20103 levels. All patients were followed up for 4 years after admission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to the nonstroke cases, serum levels of Gal\u20103 were markedly elevated in stroke cases (7.08 [IQR, 4.60\u201310.96] vs. 17.34 [IQR, 8.28\u201320.31], <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Gal\u20103 yields a superior AUC (0.748, with a 95%CI of 0.681\u20130.807) compared to other classical stroke indices, such as BNP, CHA2DS2\u2010Vas score, and TNI. Remarkably, the Gal\u20103 index exhibited a superior predictive capacity, yielding a significant incremental predictive value that surpassed the conventional risk factors (CHA2DS2\u2010VASc score) for stroke events, as evidenced by an IDI of 16.4% (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and an NRI of 34.7% (<jats:italic>p<\/jats:italic>\u2009=\u20090.002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The presence of Gal\u20103 is an independent risk factor for stroke in patients with AF. Elevated levels of Gal\u20103 have the potential to serve as a valuable biomarker for identifying incident strokes in AF patients. Furthermore, incorporating the assessment of Gal\u20103 levels into the conventional CHA2DS2\u2010VASc score could significantly enhance its predictive accuracy for stroke in AF patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.70084","type":"journal-article","created":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T07:03:48Z","timestamp":1738739028000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Predictive Value of Circulating Gal\u20103 for New Stroke Events in Paroxysmal Atrial Fibrillation Patients Despite Oral Anticoagulation Medications"],"prefix":"10.1002","volume":"48","author":[{"given":"Yihan","family":"Wang","sequence":"first","affiliation":[{"name":"School of the Third Clinical Medical College Capital Medical University Beijing People's Republic of China"},{"name":"Heart Center &amp; Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital Capital Medical University Beijing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianran","family":"Luan","sequence":"additional","affiliation":[{"name":"School of the Third Clinical Medical College Capital Medical University Beijing People's Republic of China"},{"name":"Department of Gerontology The Third People Hospital of Chengdu Sichuan People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Dong","sequence":"additional","affiliation":[{"name":"Heart Center &amp; Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital Capital Medical University Beijing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9666-456X","authenticated-orcid":false,"given":"Xiaoming","family":"Zhu","sequence":"additional","affiliation":[{"name":"Heart Center &amp; Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital Capital Medical University Beijing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.08.017"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.115.016795"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2016.106"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1474-4422(24)00037-1"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.7326\/m13-1467"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21239232"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-021-02043-0"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-022-02827-y"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2016.03.003"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.111066"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/2924773"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cwt006"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000443022"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/5284728"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2018.05.094"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/cir.0000000000001193"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.12331"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euw279"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.890635"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep40378"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867324666170918122502"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.012004"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.14503\/thij-14-4353"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.70084","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T16:16:51Z","timestamp":1741709811000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.70084"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1002\/clc.70084"],"URL":"https:\/\/doi.org\/10.1002\/clc.70084","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"2024-09-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70084"}}