{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T05:50:43Z","timestamp":1770357043941,"version":"3.49.0"},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T00:00:00Z","timestamp":1741305600000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Left atrium (LA) is an integral component of left heart remodeling, reflecting hemodynamics and ventricular status. It remains uncertain whether left atrial diameter (LAD) can be utilized for predicting and evaluating the occurrence of heart failure (HF) in middle\u2010aged and elderly individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study aimed to explore the correlation between LAD and HF in middle\u2010aged and elderly individuals, elucidating the timing of occurrence HF in relation to LAD. The retrospective\u2010prospective study investigated 4025 patients who underwent echocardiography at Zhongshan Hospital's Cardiovascular Department from January 2015 to December 2017. Patients were continuously monitored for HF until January 31, 2024. Cox regression analyses related baseline LAD to HF incidence, adjusted for known risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 4025 individuals (mean age: 55 years, 45.29% male) were studied, spanning ages 45\u201391. Fifty\u2010one developed HF during a median follow\u2010up of 4.36 years. Cox regression model demonstrated the association between HF and LAD (HR\u2009=\u20095.721, 95% CI 3.768\u20138.687, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) even after adjusting for covariates (age, weight, eGFR, HDL\u2010C, lymphocyte count, systolic blood pressure, FPG, HbA1C, waist circumference, hip circumference, valvular disease history, atrial fibrillation history).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The link between LAD and future HF occurrence risk among middle\u2010aged and older adults shows a dose\u2013response pattern. This relationship persists post\u2010adjustment for HF\u2010related factors, highlighting the predictive value of LAD in forecasting HF incidence.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.70085","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T07:17:54Z","timestamp":1741763874000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Investigating Left Atrial Diameter and Heart Failure Onset in Middle\u2010Aged and Elderly: A Retrospective\u2010Prospective Study"],"prefix":"10.1002","volume":"48","author":[{"given":"Ai","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Zhongshan Hospital Fudan University Shanghai 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