{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:44:21Z","timestamp":1753868661233,"version":"3.41.2"},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:00:00Z","timestamp":1740355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aims to evaluate the clinical efficacy and safety of ultrasound\u2010guided percutaneous septal precision chemical ablation in the treatment of hypertrophic obstructive cardiomyopathy (HOCM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From December 2020 to July 2024, 27 patients with HOCM without large target septal branches (diffuse multiple branches, all less than 1\u2009mm in diameter) were enrolled and underwent ultrasound\u2010guided percutaneous septal chemical ablation. Intraoperative left ventricular outflow tract gradient (LVOTG), postoperative cardiac troponin I (cTnI), complications, and changes in the 36\u2010Item Short Form Survey (SF\u201036) score, New York Heart Association (NYHA) functional classification and echocardiography parameters in 1 year post\u2010PTSMA were monitored and analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Immediate postoperative LVOTG values monitored by catheter and echocardiography were both significantly decreased (both <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) in the 27 patients, whereas the cTnI level was increased after PTSMA treatment (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). One patient developed transient complete right bundle branch block during the procedure. At the 1\u2010year follow\u2010up, these patients showed significantly increased scores in all the eight domains of the SF\u201036 scale, and markedly improvement in echocardiography\u2010based LVOTG value (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) and NYHA functional classification (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). However, no significant change were observed in the mean interventricular septal thickness (IVSTh) and left ventricular ejection fraction (LVEF) before and after operation (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Ultrasound\u2010guided precision PTSMA with gelatin sponge is a safe and effective treatment approach for HOCM patients, which can reduce the left ventricular outflow tract obstruction and greatly improve the life quality of the patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.70095","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T12:57:39Z","timestamp":1741697859000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Clinical Study of Precision Chemoablation for Hypertrophic Obstructive Cardiomyopathy Without Large Interventricular Septal Branches"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3207-8667","authenticated-orcid":false,"given":"Xinnan","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Cardiology, Affiliated Hospital of Nantong University Medical School of Nantong University Nantong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Affiliated Hospital of Nantong University Medical School of Nantong University Nantong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haihua","family":"Geng","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Affiliated Hospital of Nantong University Medical School of Nantong University Nantong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Affiliated Hospital of Nantong University Medical School of Nantong University Nantong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Affiliated Hospital of Nantong University Medical School of Nantong University Nantong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peishu","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Affiliated Hospital of Nantong University Medical School of Nantong University Nantong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yufeng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Affiliated Hospital of Nantong University Medical School of Nantong University Nantong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology Medical School of Nantong University Nantong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongzhuan","family":"Sheng","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Affiliated Hospital of Nantong University Medical School of Nantong University Nantong China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000938"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/0366-6999.226075"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10112276"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.20500"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.29178"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/2048004016636313"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.21037\/acs.2017.05.09"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.15167\/2421-4248\/jpmh2022.63.1.2279"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-016-0467-x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2022.06.034"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.70095","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T19:27:11Z","timestamp":1743276431000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.70095"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,24]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1002\/clc.70095"],"URL":"https:\/\/doi.org\/10.1002\/clc.70095","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"type":"print","value":"0160-9289"},{"type":"electronic","value":"1932-8737"}],"subject":[],"published":{"date-parts":[[2025,2,24]]},"assertion":[{"value":"2023-11-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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