{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T22:04:27Z","timestamp":1782511467108,"version":"3.54.5"},"reference-count":62,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Although some guidelines recommend Renal denervation (RDN) as an alternative to anti\u2010HTN medications, there are concerns about its efficacy and safety. We aimed to evaluate the benefits and harms of RDN in a systematic review and meta\u2010analysis of sham\u2010controlled randomized clinical trials (RCT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Databases were searched until September 10th, 2024, to identify RCTs evaluating RDN for treating URH versus sham control. The primary outcomes were the change in office and ambulatory 24\u2010h systolic (SBP) and diastolic blood pressure (DBP). Secondary outcomes were changes in daytime and nighttime SBP and DBP, home BP, number of anti\u2010HTN drugs, and related complications. Mean differences (MD) and relative risks (RR) described the effects of RDN on BP and complications, respectively, using random effects meta\u2010analyses. GRADE methodology was used to assess the certainty of evidence (COE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found 16 included sham\u2010controlled RCTs [RDN (<jats:italic>n<\/jats:italic>\u2009=\u20091594) vs. sham (<jats:italic>n<\/jats:italic>\u2009=\u20091225)]. RDN significantly reduced office SBP (MD \u22124.26\u2009mmHg, 95% CI: \u22125.68 to \u22122.84), 24\u2009h ambulatory SBP (MD \u22122.63\u2009mmHg), office DBP (MD \u22122.15\u2009mmHg), 24\u2010h ambulatory DBP (MD \u22121.27\u2009mmHg), and daytime SBP and DBP (MD \u22123.29 and 2.97\u2009mmHg), compared to the sham. The rate of severe complications was low in both groups (0%\u20132%). The heterogeneity was high among most indices, and CoE was very low for most outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>RDN significantly reduced several SBP and DBP outcomes versus sham without significantly increasing complications. This makes RDN a potentially effective alternative to medications in URH.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.70104","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T05:23:01Z","timestamp":1741756981000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Renal Denervation Effects on Blood Pressure in Resistant and Uncontrolled Hypertension: A Meta\u2010Analysis of Sham\u2010Controlled Randomized Clinical Trials"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2802-4613","authenticated-orcid":false,"given":"Hamidreza","family":"Soleimani","sequence":"first","affiliation":[{"name":"Imam Khomeini Hospital Complex, Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babak","family":"Sattartabar","sequence":"additional","affiliation":[{"name":"Tehran Heart Center, Cardiovascular 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