{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:10:06Z","timestamp":1782778206666,"version":"3.54.5"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T00:00:00Z","timestamp":1742256000000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Traditional right ventricular pacing (RVP) can lead to asynchronous cardiac mechanical contractions and increase the risk of atrial fibrillation (AF). This study aimed to compare the occurrence of new\u2010onset AF and the progression of AF between novel physiological pacing\u2014left bundle branch area pacing (LBBAP) and RVP with a long\u2010term follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Patients with a dual\u2010chamber permanent pacemaker initial implantation, no history of persistent AF, and an expected high proportion of ventricular pacing (VP\u2009\u2265\u200920%) were included in this retrospective cohort study (LBBAP, <jats:italic>n<\/jats:italic>\u2009=\u2009122; RVP, <jats:italic>n<\/jats:italic>\u2009=\u2009166). The pacing QRS duration (QRSd) of the LBBAP was significantly shorter than that of the RVP (113\u2009\u00b1\u200922 vs. 140\u2009\u00b1\u200927\u2009ms, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), while the intrinsic QRSd values from the two groups were comparable. During a mean follow\u2010up of 21.9\u2009\u00b1\u20099.4 months, the composite outcome of postoperative new\u2010onset AF or AF progression was higher in the RVP group than in the LBBAP group (RVP HR 2.62, 95%CI 1.21\u20135.67, <jats:italic>p<\/jats:italic>\u2009=\u20090.014). Left ventricular end\u2010diastolic diameter (LVEDD) levels decreased in the LBBAP group at 1 year follow\u2010up (50\u2009\u00b1\u20096 vs. baseline 48\u2009\u00b1\u20096, <jats:italic>p<\/jats:italic>\u2009=\u20090.002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In a mean follow\u2010up period of 2 years, compared to RVP, LBBAP patients with VP\u2009\u2265\u200920% had a decreased risk of occurrence and progression of AF events.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.70116","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T12:00:50Z","timestamp":1742299250000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Long\u2010Term Effects of Left Bundle Branch Area Pacing Versus Traditional Right Ventricular Pacing on Atrial Fibrillation After Dual\u2010Chamber Pacemaker Implantation"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7687-4431","authenticated-orcid":false,"given":"Jieruo","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Cardiology Beijing Anzhen Hospital, Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zefeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Beijing Anzhen Hospital, Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Hang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Beijing Anzhen Hospital, Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiping","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Cardiology Beijing Anzhen Hospital, Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiwei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology Beijing Anzhen Hospital, Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9156-4669","authenticated-orcid":false,"given":"Yongquan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Beijing Anzhen Hospital, Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,18]]},"reference":[{"issue":"11","key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1093\/europace\/euw024","article-title":"Heart Failure Due to Right Ventricular Apical Pacing: The Importance of Flow Patterns","volume":"18","author":"Cicchitti V.","year":"2016","journal-title":"Europace"},{"issue":"2","key":"e_1_2_12_3_1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.tcm.2021.10.013","article-title":"Adverse Effects of Right Ventricular Pacing on Cardiac Function: Prevalence, Prevention and Treatment With Physiologic Pacing","volume":"33","author":"Naqvi T. Z.","year":"2023","journal-title":"Trends in Cardiovascular Medicine"},{"issue":"12","key":"e_1_2_12_4_1","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1016\/j.cjca.2017.09.013","article-title":"A Novel Pacing Strategy With Low and Stable Output: Pacing the Left Bundle Branch Immediately Beyond the Conduction Block","volume":"33","author":"Huang W.","year":"2017","journal-title":"Canadian Journal of Cardiology"},{"issue":"9","key":"e_1_2_12_5_1","first-page":"1178","article-title":"The Burden of Proof in Defining Conduction Pacing Criteria","volume":"7","author":"Tung R.","year":"2021","journal-title":"JACC: Clinical Electrophysiology"},{"issue":"11","key":"e_1_2_12_6_1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s11886-021-01585-1","article-title":"Left Bundle Branch Area Pacing: Implant Technique, Definitions, Outcomes, and Complications","volume":"23","author":"Cano \u00d3.","year":"2021","journal-title":"Current Cardiology Reports"},{"issue":"2","key":"e_1_2_12_7_1","article-title":"Long\u2010Term Safety and Feasibility of Left Bundle Branch Pacing in a Large Single\u2010Center Study","volume":"14","author":"Su L.","year":"2021","journal-title":"Circulation: Arrhythmia and Electrophysiology"},{"issue":"8","key":"e_1_2_12_8_1","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/j.hrthm.2023.05.010","article-title":"Improved Outcomes of Conduction System Pacing in Heart Failure With Reduced Ejection Fraction: A Systematic Review and Meta\u2010Analysis","volume":"20","author":"Gin J.","year":"2023","journal-title":"Heart Rhythm"},{"key":"e_1_2_12_9_1","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2023.1246846","article-title":"Feasibility and Safety of Left Bundle Branch Area Pacing for Patients With Stable Coronary Artery Disease","volume":"10","author":"Shan Y.","year":"2023","journal-title":"Frontiers in Cardiovascular Medicine"},{"issue":"4","key":"e_1_2_12_10_1","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1093\/europace\/euy252","article-title":"Comparison of Electrocardiogram Characteristics and Pacing Parameters Between Left Bundle Branch Pacing and Right Ventricular Pacing in Patients Receiving Pacemaker Therapy","volume":"21","author":"Chen K.","year":"2019","journal-title":"Europace"},{"issue":"22","key":"e_1_2_12_11_1","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.018478","article-title":"Development of New\u2010Onset or Progressive Atrial Fibrillation in Patients With Permanent HIS Bundle Pacing Versus Right Ventricular Pacing: Results From the RUSH HBP Registry","volume":"9","author":"Ravi V.","year":"2020","journal-title":"Journal of the American Heart Association"},{"issue":"6","key":"e_1_2_12_12_1","first-page":"844","article-title":"Efficacy of Low Interatrial Septum and Right Atrial Appendage Pacing for Prevention of Permanent Atrial Fibrillation in Patients With Sinus Node Disease: Results From the Electrophysiology\u2010Guided Pacing Site Selection (EPASS) Study","volume":"4","author":"Verlato R.","year":"2011","journal-title":"Circulation: Arrhythmia and Electrophysiology"},{"issue":"3","key":"e_1_2_12_13_1","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1093\/europace\/euv268","article-title":"The Risk of Atrial Fibrillation During Right Ventricular Pacing","volume":"18","author":"Pastore G.","year":"2016","journal-title":"Europace"},{"issue":"5","key":"e_1_2_12_14_1","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1161\/CIRCULATIONAHA.123.067465","article-title":"Arrhythmic Risk in Biventricular Pacing Compared With Left Bundle Branch Area Pacing: Results From the I\u2010CLAS Study","volume":"149","author":"Herweg B.","year":"2024","journal-title":"Circulation"},{"issue":"13","key":"e_1_2_12_15_1","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1161\/CIRCULATIONAHA.123.067512","article-title":"Direct Oral Anticoagulants for Stroke Prevention in Patients With Device\u2010Detected Atrial Fibrillation: A Study\u2010Level Meta\u2010Analysis of the NOAH\u2010AFNET 6 and ARTESiA Trials","volume":"149","author":"Mcintyre W. F.","year":"2024","journal-title":"Circulation"},{"issue":"3","key":"e_1_2_12_16_1","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.ijcard.2010.12.075","article-title":"Left Atrial Remodeling and Reduced Atrial Pump Function After Chronic Right Ventricular Apical Pacing in Patients With Preserved Ejection Fraction","volume":"157","author":"Xie J. M.","year":"2012","journal-title":"International Journal of Cardiology"},{"issue":"19","key":"e_1_2_12_17_1","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.15053","article-title":"Left Atrial Conduit Function: A Short Review","volume":"9","author":"Marino P. N.","year":"2021","journal-title":"Physiological Reports"},{"issue":"7","key":"e_1_2_12_18_1","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1093\/europace\/eut436","article-title":"Hisian Area and Right Ventricular Apical Pacing Differently Affect Left Atrial Function: An Intra\u2010Patients Evaluation","volume":"16","author":"Pastore G.","year":"2014","journal-title":"Europace"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.70116","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T19:24:37Z","timestamp":1743276277000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.70116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1002\/clc.70116"],"URL":"https:\/\/doi.org\/10.1002\/clc.70116","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"2025-01-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70116"}}