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However, the clinical outcomes and prognostic implications of TAVR in patients with active cancer remain uncertain. This meta\u2010analysis evaluates procedural success, complications, and survival outcomes of TAVR in patients with and without active cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A comprehensive literature search was conducted across PubMed, Scopus, and Web of Science databases. Statistical analysis was performed using a random\u2010effects model. Statistical analyses were conducted using STATA version 18.0.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results of the meta\u2010analysis showed no significant difference in in\u2010hospital mortality between cancer and non\u2010cancer patients (OR\u2009=\u20091.17; 95% CI: 0.83, 1.65; <jats:italic>p<\/jats:italic>\u2009=\u20090.27). Similarly, 30\u2010day mortality did not differ between the two groups (OR\u2009=\u20090.93; 95% CI: 0.72, 1.19; <jats:italic>p<\/jats:italic>\u2009=\u20090.49). However, 1\u2010year mortality was significantly higher in cancer patients (OR\u2009=\u20091.93; 95% CI: 1.45, 2.56; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). Two\u2010year mortality was also higher in cancer patients (OR\u2009=\u20092.65; 95% CI: 1.79, 3.93; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). No significant differences were observed in major bleeding, acute kidney injury, stroke, or permanent pacemaker implantation between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>While TAVR offers comparable in\u2010hospital and short\u2010term survival outcomes for cancer and non\u2010cancer patients, long\u2010term mortality is significantly higher in those with active cancer. These findings suggest that TAVR is a viable option for cancer patients with severe AS but requires careful long\u2010term prognostic considerations. Further studies are needed to optimize management strategies for this complex population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.70121","type":"journal-article","created":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T23:34:30Z","timestamp":1742859270000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Clinical Outcomes and Prognostic Implications of TAVR in Patients With Active Cancer: A Meta\u2010Analysis"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8889-8630","authenticated-orcid":false,"given":"Parsa","family":"Saberian","sequence":"first","affiliation":[{"name":"Cardiovascular Research Center Hormozgan University of Medical Sciences Bandar Abbas Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6333-6394","authenticated-orcid":false,"given":"Rafael","family":"Contreras","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yale New Heaven Health Bridgeport Hospital 267 Grant St Bridgeport CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4225-2986","authenticated-orcid":false,"given":"Anoop","family":"Gurram","sequence":"additional","affiliation":[{"name":"Department of Hospital Medicine Cleveland Clinic Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6328-8468","authenticated-orcid":false,"given":"Amir","family":"Nasrollahizadeh","sequence":"additional","affiliation":[{"name":"Tehran Heart Center, Cardiovascular Diseases Research Institute Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narsimha Rao","family":"Keetha","sequence":"additional","affiliation":[{"name":"Ohio Kidney and Hypertension Center 7255 Middleburg Hts OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony Loc","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Internal Medicine UC San Diego Health Moores Cancer Center San Diego CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep Samethadka","family":"Nayak","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yale New Heaven Health Bridgeport Hospital 267 Grant St Bridgeport CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad\u2010Hossein","family":"Keivanlou","sequence":"additional","affiliation":[{"name":"School of Medicine Guilan University of Medical Sciences Rasht Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Hashemi","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center Hormozgan University of Medical Sciences Bandar Abbas Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4985-2899","authenticated-orcid":false,"given":"Ehsan","family":"Amini\u2010Salehi","sequence":"additional","affiliation":[{"name":"School of Medicine Guilan University of Medical Sciences Rasht Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniyal","family":"Ameen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yale New Heaven Health Bridgeport Hospital 267 Grant St Bridgeport CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,24]]},"reference":[{"issue":"2","key":"e_1_2_14_2_1","doi-asserted-by":"crossref","first-page":"s6","DOI":"10.1136\/heartjnl-2018-313511","article-title":"Clinical Trials of Transcatheter Aortic Valve Replacement","volume":"105","author":"Al\u2010Azizi K.","year":"2019","journal-title":"Heart"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2021.01.042"},{"issue":"1","key":"e_1_2_14_4_1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/nrcardio.2010.197","article-title":"Tavi\u2014Better Than SAVR In High\u2010Risk Patients?","volume":"8","author":"Ray K.","year":"2011","journal-title":"Nature Reviews Cardiology"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.03.496"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.030072"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.030072"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acvd.2023.08.001"},{"issue":"13","key":"e_1_2_14_9_1","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1136\/heartjnl-2023-323039","article-title":"Heartbeat: Cancer History and Risk of Cardiovascular Disease","volume":"109","author":"Otto C. 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