{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T13:57:52Z","timestamp":1782136672383,"version":"3.54.5"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T00:00:00Z","timestamp":1747094400000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to compare the lipid\u2010lowering effect and safety of low\u2010intensity atorvastatin (5\u2009mg) plus ezetimibe (10\u2009mg) combination therapy (A5E10) with monotherapy regimens\u2013atorvastatin 5\u2009mg [A5], ezetimibe 10\u2009mg [E10], and atorvastatin 10\u2009mg [A10])\u2013in dyslipidemia patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A randomized, double\u2010blind, placebo\u2010controlled trial involving 252 dyslipidemia patients was conducted at 25 centers in South Korea (NCT05970679). Participants aged \u2265\u200919 years were randomized into four groups: A5E10, A5, E10, and A10. The primary endpoint was the percentage change in low\u2010density lipoprotein cholesterol (LDL\u2010C) levels from baseline to 8 weeks. Secondary endpoints included changes in other lipid parameters, lipid ratios, LDL\u2010C goal achievement rates and safety assessments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age of the patients was 63 years, and 51.2% were male. The A5E10 group showed significantly greater LDL\u2010C reduction (47.6%) compared with A5 (33.4%), E10 (19.4%), and A10 (40.1%) at 8 weeks (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). A5E10 also significantly reduced triglyceride, non\u2010high\u2010density lipoprotein cholesterol, and apolipoprotein B levels. In addition, a significant reduction in LDL\u2010C levels was observed over the 4 weeks, with a 46.7% reduction in LDL\u2010C levels after 4 weeks of A5E10 administration. No severe adverse events were observed in the A5E10 group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The combination of low\u2010intensity atorvastatin and ezetimibe was more effective than moderate\u2010intensity atorvastatin monotherapy in lowering LDL\u2010C levels and improving other lipid parameters. It was well\u2010tolerated and demonstrated rapid benefits within a month, offering a promising alternative for patients with low to moderate cardiovascular risk who do not achieve adequate control with statin monotherapy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.70138","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T11:05:14Z","timestamp":1747134314000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Lipid\u2010Lowering Effect and Safety of Ezetimibe and Atorvastatin 5\u2009mg in Patients With Primary Hypercholesterolemia or Mixed Dyslipidemia: A Randomized, Double\u2010Blind, Parallel, Multicenter, Phase 3 Clinical Trial"],"prefix":"10.1002","volume":"48","author":[{"given":"You\u2010Jeong","family":"Ki","sequence":"first","affiliation":[{"name":"Cardiovascular Center, Department of Internal Medicine Uijeongbu Eulji Medical Center Uijeongbu Republic of 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