{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:56:26Z","timestamp":1782604586907,"version":"3.54.5"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:00:00Z","timestamp":1747180800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Left atrial appendage occlusion (LAAO) is an established therapy for stroke prevention in non\u2010valvular atrial fibrillation (NVAF), but outcomes in Hispanic populations remain underexplored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of our study was to evaluate the inpatient outcomes of Hispanic patients undergoing LAAO as compared to non\u2010Hispanic white patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective cohort study using the National Inpatient Sample (NIS). From 157\u2009434 LAAO hospitalizations identified, 133\u2009517 were non\u2010Hispanic white and 6814 were Hispanic\/Latino. The primary outcome was in\u2010hospital mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Unadjusted odds in the Hispanic\/Latino group were higher for mortality (OR 1.78, 95% CI 1.18\u22122.68, <jats:italic>p<\/jats:italic> 0.006), stroke (OR 1.64, 95% CI 1.26\u22122.14, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), infectious complications (OR 3.89, 95% CI 3.03\u22124.99, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), major bleeding (OR 1.22, 95% CI 1.11\u22121.33, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), DVT\/PE (OR 2.15, 95% CI 1.58\u22122.93, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and vascular complications (OR 1.81, 95% CI 0.53\u22120.93, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). After adjusting for covariates and comorbidities, Hispanic\/Latino patients had still greater odds of mortality (aOR 1.20, 95% CI 0.75\u22121.92, <jats:italic>p<\/jats:italic> 0.445), infectious complications (aOR 3.54, 95% CI 2.62\u22124.55, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and vascular complications (aOR 1.57, 95% CI 1.22\u22122.03, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Non\u2010Hispanic white patients had higher adjusted odds of pericardial effusion\/tamponade (aOR 0.64, 95% CI 0.52\u22120.95, <jats:italic>p<\/jats:italic> 0.03), while Hispanic\/Latino patients also had higher adjusted odds of cardiac arrest (aOR 1.99, 95% CI 1.15\u22123.42, <jats:italic>p<\/jats:italic> 0.46).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Hispanic\/Latino patients undergoing LAAO experience higher odds of infectious and vascular complications compared to non\u2010Hispanic white patients. These findings highlight the need to further investigate disparities in procedural outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.70152","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T10:14:06Z","timestamp":1747217646000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Outcomes of Left Atrial Appendage Occlusion in Hispanic\/Latino Patients: Insights From the National Inpatient Sample"],"prefix":"10.1002","volume":"48","author":[{"given":"Mashli","family":"Fleurestil","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Internal Medicine University of Miami Miller School of Medicine Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0639-9732","authenticated-orcid":false,"given":"Ayush","family":"Mohan","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Internal Medicine University of Miami Miller School of Medicine Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Ergui","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Internal Medicine University of Miami Miller School of Medicine Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacklyn","family":"Samaha","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Internal Medicine University of Miami Miller School of Medicine Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosario","family":"Colombo","sequence":"additional","affiliation":[{"name":"Department of Cardiology Jackson Memorial Hospital Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul","family":"Mitrani","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology University of Miami Miller School of Medicine Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"de Marchena","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology University of Miami Miller School of Medicine Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Villablanca","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology Henry Ford Health Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Wiley","sequence":"additional","affiliation":[{"name":"Section of Cardiology, Department of Medicine Tulane University New Orleans Los Angeles USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiannis S.","family":"Chatzizisis","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology University of Miami Miller School of Medicine Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Cox","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology University of Miami Miller School of Medicine Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2024.10.024"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/circoutcomes.121.008418"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.06.046"},{"key":"e_1_2_11_5_1","unstructured":"V. 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K.Doshi S.Kar et al. 5\u2010Year Outcomes After Left Atrial Appendage Closure From the PREVAIL and PROTECT AF Trials on behalf of the PREVAIL and PROTECT AF Investigators ABSTRACT BACKGROUND The PROTECT AF (WATCHMAN Left Atrial Appendage System for Embolic Protection in Patients with. 2017."},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2023.07.040"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-023-01910-w"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hroo.2022.12.007"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.121.008418"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnma.2023.02.008"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.12.040"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.028806"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2022.11.009"},{"key":"e_1_2_11_14_1","volume-title":"Current Problems in Cardiology","author":"Alhuneafat L.","year":"2022"},{"key":"e_1_2_11_15_1","first-page":"E1\u2013E156","volume-title":"Circulation","author":"Joglar J. 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