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Assessment of right ventricular (RV) function through 2D\u2010STE has demonstrated impaired right ventricular free wall longitudinal strain (RVFWLS) and global longitudinal strain (RVGLS) in individuals with T2DM, which correlates with suboptimal glycemic control. Furthermore, evaluation of left ventricular (LV) function has revealed decreased global longitudinal strain (GLS) and impaired LV twist mechanics in T2DM patients, particularly under conditions of physiological stress.<\/jats:p><jats:p>In T1DM patients, 2D\u2010STE has identified early changes in myocardial deformation, with studies reporting reduced LV and RV strain values compared to healthy controls. The technique has also been effective in assessing the impact of disease duration and glycemic control on cardiac function in both T1DM and T2DM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings underscore the potential of 2D\u2010STE as a sensitive and comprehensive tool for early detection of cardiac dysfunction in both T1DM and T2DM, potentially guiding management strategies and improving outcomes in these high\u2010risk populations.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.70153","type":"journal-article","created":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T05:20:22Z","timestamp":1747977622000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["A Comprehensive Review of Two\u2010Dimensional Speckle\u2010Tracking Echocardiography in Assessing Right and Left Ventricular Function in Diabetic Patients"],"prefix":"10.1002","volume":"48","author":[{"given":"Azin","family":"Alizadehasl","sequence":"first","affiliation":[{"name":"Cardio\u2010Oncology Research Center, Rajaie Cardiovascular Medical and Research Center Iran University of Medical Sciences Tehran Iran"},{"name":"Echocardiography Research Center, Rajaie Cardiovascular Medical and Research Center Iran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahshid","family":"Mokhayeri","sequence":"additional","affiliation":[{"name":"Echocardiography Research Center, Rajaie Cardiovascular Medical and Research Center Iran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeynab","family":"Sohani","sequence":"additional","affiliation":[{"name":"Echocardiography Research Center, Rajaie Cardiovascular Medical and Research Center Iran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0944-0320","authenticated-orcid":false,"given":"Mohammad Yasin","family":"Zamanian","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, School of Medicine Hamadan University of Medical Science Hamadan Iran"},{"name":"Department of Physiology, School of Medicine Hamadan University of Medical Sciences Hamadan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parai","family":"Shahbazi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, School of Medicine Hamadan University of Medical Sciences Hamadan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiva","family":"Borzouei","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, School of Medicine Hamadan University of Medical Science Hamadan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,22]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2022.108167"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2024.09.002"},{"issue":"9","key":"e_1_2_15_4_1","article-title":"Cardiovascular Complications of Diabetes: From Microvascular to Macrovascular Pathways","volume":"15","author":"Zakir M.","year":"2023","journal-title":"Cureus"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11041126"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-021-10200-y"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2023.108406"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-019-05009-2"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-023-02810-4"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000504532"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/echo.15650"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/14791641221118622"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/echo.14400"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.5603\/EP.a2022.0041"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani11082361"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2017.06.016"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.4103\/apc.apc_91_21"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.3329\/cardio.v11i2.40418"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13144037"},{"key":"e_1_2_15_20_1","first-page":"4825","article-title":"Clinical Applications of Left Ventricular Global Longitudinal Strain by 2D\u2010Speckle Tracking Echocardiography","volume":"9","author":"Alsayed M. 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