{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T19:02:15Z","timestamp":1789758135156,"version":"4.0.1"},"reference-count":12,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T00:00:00Z","timestamp":1747872000000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Immune checkpoint inhibitors (ICIs) are associated with myocarditis, which is rare but has a high mortality. This study aimed to describe cases of ICI\u2010related myocarditis at the University of Iowa Hospitals &amp; Clinics and, in doing so, provide valuable insights into patient characteristics, treatment, and outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This single\u2010center observational registry included cases of ICI\u2010related myocarditis identified from 2009 to 2024. Data were collected retrospectively from electronic medical records and included demographics, cardiovascular risk factors, medications, and cancer characteristics. Between\u2010group comparisons for continuous data were conducted using unpaired Student's\n                      <jats:italic>t<\/jats:italic>\n                      \u2010tests or the Wilcoxon rank\u2010sum test. Categorical data were analyzed with Fisher's exact test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eighteen patients were included. The mean age was 74\u2009\u00b1\u20099.4 years with 61% being male. Compared to controls, patients with ICI\u2010related myocarditis had a significantly higher prevalence of coronary artery disease (36.8% vs. 7.5%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01) and obstructive sleep apnea (33% vs. 10%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03). They were less likely to have a normal sinus rhythm on baseline electrocardiogram (50% vs. 70%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01) and more likely to suffer from a major adverse cardiac event (MACE) (38.9% vs. 2.5%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). Twelve (66.7%) of patients with ICI\u2010related myocarditis also had myasthenia gravis\u2010like overlap syndrome and 9 (50%) had myositis\/rhabdomyolysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ICI\u2010related myocarditis at a tertiary care center is rare with a calculated incidence of 0.48%. Despite this, the disease has a high incidence of MACE. Patients with pre\u2010existing cardiovascular disease are at higher risk of developing ICI\u2010related myocarditis. Careful cardiovascular monitoring in patients undergoing ICI therapy is warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/clc.70154","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T04:40:13Z","timestamp":1747888813000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Immune Checkpoint Inhibitor\u2010Related Myocarditis: A Single Center Observational Registry"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4832-5775","authenticated-orcid":false,"given":"Grace","family":"Alexander","sequence":"first","affiliation":[{"name":"Department of Medicine University of Iowa Hospitals &amp; Clinics Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Mortada","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Iowa Hospitals &amp; Clinics Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Mhanna","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology University of Iowa Hospitals &amp; Clinics Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Byer","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Iowa Hospitals &amp; Clinics Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Udhayvir Singh","family":"Grewal","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hematology, Oncology, and Blood &amp; Marrow Transplantation University of Iowa Hospitals &amp; Clinics Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shareef","family":"Mansour","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology University of Iowa Hospitals &amp; Clinics Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1609214"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.02.037"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2018.3923"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30608-9"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30533-6"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.013757"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.77.6385"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.34616"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpcardiol.2022.101478"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.121.055816"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.00634"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/onco.13931"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.70154","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T02:08:25Z","timestamp":1748484505000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.70154"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":12,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1002\/clc.70154"],"URL":"https:\/\/doi.org\/10.1002\/clc.70154","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"2025-03-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70154"}}