{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:32:23Z","timestamp":1790375543424,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T00:00:00Z","timestamp":1748822400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acute coronary syndrome (ACS) remains a major contributor to cardiovascular morbidity and mortality. Cardiac rehabilitation programs have shown promise in improving adherence to lifestyle and medical recommendations, yet their impact on clinical outcomes and complications requires further investigation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective, randomized, single\u2010center study evaluated the effects of cardiac rehabilitation on adherence and clinical outcomes in ACS patients. A total of 340 patients were randomized into a Cardiac Rehabilitation Group or Control Group. The Cardiac Rehabilitation Group underwent supervised exercise, dietary counseling, and education, while the Control Group received standard recommendations. Outcomes, including adherence rates and complications, were assessed over 1 year, with additional interim analyses to evaluate early sustainability of behavioral changes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients in the Cardiac Rehabilitation Group demonstrated significant improvements in adherence to dietary recommendations (73.5% vs. 52.4%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01) and physical activity (85.3% vs. 68.2%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). Cardiac Rehabilitation Group patients also experienced fewer instances of weight gain (22.9% vs. 34.7%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.017) and access site complications (21.2% vs. 40%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). Hospital readmissions were reduced in the Cardiac Rehabilitation Group compared to the Control Group (18.8% vs. 31.2%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.015). Non\u2010adherence to dietary recommendations (HR: 2.42, 95% CI: 1.08\u20135.41,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.032) and medical treatments (HR: 2.84, 95% CI: 1.32\u20136.11,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007) were significantly associated with increased risk of revascularization.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Cardiac rehabilitation significantly enhances adherence to medical and lifestyle recommendations, reduces complications, and improves outcomes in ACS patients. These findings emphasize the critical role of structured rehabilitation in post\u2010ACS management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/clc.70160","type":"journal-article","created":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T08:25:13Z","timestamp":1748852713000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Effectiveness of Cardiac Rehabilitation in Enhancing Adherence and Improving Clinical Outcomes Post\u2010Acute Coronary Syndrome: A Randomized Controlled Trial"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2356-1460","authenticated-orcid":false,"given":"Ha\u015fim","family":"T\u00fcner","sequence":"first","affiliation":[{"name":"Department of Cardiology Istanbul Arel University Memorial Bahcelievler Hospital \u0130stanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6414-3743","authenticated-orcid":false,"given":"Fuat","family":"Polat","sequence":"additional","affiliation":[{"name":"Department of Cardiology Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Educat\u0131on Research Hosp\u0131tal \u0130stanbul T\u00fcrkiye"},{"name":"Health Sciences University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0517-6243","authenticated-orcid":false,"given":"Enes","family":"Al\u0131\u00e7","sequence":"additional","affiliation":[{"name":"Department of Cardiology Istanbul Aydin University VM Medical Park Florya Hospital \u0130stanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0917-6144","authenticated-orcid":false,"given":"Ali Nail","family":"Kaya","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hakkari State Hospital Hakkari T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5337-5226","authenticated-orcid":false,"given":"\u00c7i\u011fdem Bahar","family":"\u00c7akmak","sequence":"additional","affiliation":[{"name":"Department of Cardiology Samsun Gazi State Hospital Samsun T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4873-273X","authenticated-orcid":false,"given":"Ferhat","family":"Co\u015fkun","sequence":"additional","affiliation":[{"name":"Department of Cardiology Batman Health Sciences University Training and Research Hospital Batman T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0724-6700","authenticated-orcid":false,"given":"Emrah","family":"\u00d6zbek","sequence":"additional","affiliation":[{"name":"Department of Cardiology Van Health Sciences University Training and Research Hospital Van T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,2]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0903515"},{"issue":"19","key":"e_1_2_12_3_1","first-page":"2031","article-title":"In\u2010Hospital Use of Secondary Prevention Therapies for Acute Myocardial Infarction: An Analysis of the CRUSADE Quality Improvement Initiative","volume":"164","author":"Bagai A.","year":"2014","journal-title":"Archives of Internal Medicine"},{"issue":"1","key":"e_1_2_12_4_1","first-page":"96","article-title":"Medical Therapy for Secondary Prevention and Beyond in Patients Undergoing Coronary Revascularization","volume":"39","author":"Gallone G.","year":"2018","journal-title":"European Heart Journal"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.180945"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-668X(03)00198-2"},{"issue":"1","key":"e_1_2_12_7_1","first-page":"32","article-title":"A Review of Telerehabilitation for Cardiac Patients","volume":"23","author":"Frederix I.","year":"2017","journal-title":"Journal of Telemedicine and Telecare"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1559827613488867"},{"issue":"2","key":"e_1_2_12_9_1","first-page":"34S","article-title":"The LEARN Program for Weight Management","volume":"7","author":"Brownell K. 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