{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T10:03:24Z","timestamp":1770977004020,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T00:00:00Z","timestamp":1749600000000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100008376","name":"Helsingin ja Uudenmaan Sairaanhoitopiiri","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008376","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The prognosis of acute heart failure (AHF) remains poor. Studies focusing on the time\u2010sensitivity of early AHF management have reported controversial results. Thus, our aim is to review current studies focusing on AHF patients using emergency medical services (EMS), their early management, and patient outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched the recent literature in PubMed and Scopus for studies comparing AHF patients arriving at the hospital by EMS to those self\u2010presenting (non\u2010EMS) at ED (emergency department) from database inception until November 2022.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The literature search found five studies fulfilling our inclusion criteria. The percentage of AHF patients using EMS varied in these studies: 11.5% (100\/873) in Finnish FINN\u2010AKVA II, 22.1% (236\/1068) in Canadian ASCEND\u2010HF, 35.5% (5129\/14454) in a Pakistan Heart Failure\u2010registry study, 52.8% (3224\/6106) in Spanish SEMICA, and 61.8% (309\/500) in the European EURODEM study. The pre\u2010hospital management differed across the reviewed studies. The use of NIV was rare, ranging from zero to four percent. Vasodilators and diuretics were more commonly used. Although, the differences in the use were obvious (range from 7.1% to 22.0%, and 0.0% to 29.0% accordingly). Three of the studies reported significantly higher 30\u2010day mortality among EMS patients compared to non\u2010EMS patients: ranging from 5.6% versus 3.5%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001% to 15.0% versus 6.9%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The use of EMS, as well as pre\u2010hospital management, varies between the international cohorts and registries. The pre\u2010hospital AHF management is generally limited. Moreover, EMS patients tend to have worse outcomes compared to non\u2010EMS patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/clc.70161","type":"journal-article","created":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T07:19:46Z","timestamp":1749626386000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Initial Care Pathway in Acute Heart Failure From Home to Hospital"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2425-3080","authenticated-orcid":false,"given":"Pia","family":"Harjola","sequence":"first","affiliation":[{"name":"Emergency Medicine University of Helsinki and Department of Emergency Medicine and Services, Helsinki University Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veli\u2010Pekka","family":"Harjola","sequence":"additional","affiliation":[{"name":"Emergency Medicine University of Helsinki 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