{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T18:14:08Z","timestamp":1761761648361,"version":"build-2065373602"},"reference-count":56,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:00:00Z","timestamp":1760572800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Coronary artery disease (CAD) is a common comorbidity in patients with atrial fibrillation (AF), and optimal antithrombotic medication improves clinical outcomes in this high\u2010risk population. The aim of our study was to describe antithrombotic drug regimens in different patient cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We investigated data from the prospective Helios Heart registry (H2) and the Heart Center Leipzig routine clinical database (HZL). We included inpatient cases with AF and CAD (hospitalized from March 2021 to July 2024 [H2] or January 2017 to December 2021 [HZL]), who underwent percutaneous coronary intervention (PCI) within the last 12 months. Information on clinical characteristics, coronary interventions, and medication prescribed was obtained from electronic case report forms and\/or administrative data based on ICD\u201010, OPS, and ATC codes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 3481 (HZL), and 205 (H2) index cases with comparable baseline characteristics. Overall, 92.5% (HZL) and 87.6% (H2) of patients were on any anticoagulation, and 93.0% (HZL) and 80.2% (H2) were prescribed \u2265\u20091 antiplatelet agent. There were relevant differences in antithrombotic therapy when stratifying for PCI timing. Factors associated with higher (older age) or lower (comorbidity burden, antiplatelet treatment, prior left atrial appendage occlusion) prescription rates of OAC were identified. OAC therapy without adjunctive antiplatelet therapy was associated with an increased rate of rehospitalization for major adverse cardiovascular events at 12 months (HZL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We presented current data on antithrombotic drug utilization in patients with AF and CAD and found comorbidity burden, concomitant antiplatelet treatment and other factors to be associated with lower anticoagulant prescription rates.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/clc.70196","type":"journal-article","created":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T10:42:02Z","timestamp":1760611322000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Management of Antithrombotic Therapy in Patients With Coexisting Atrial Fibrillation and Coronary Artery Disease Who Underwent Percutaneous Coronary Intervention Within the Last Year"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3759-3052","authenticated-orcid":false,"given":"Sebastian","family":"K\u00f6nig","sequence":"first","affiliation":[{"name":"Department of Electrophysiology Heart Center Leipzig at University of Leipzig Leipzig Germany"},{"name":"Helios Health Institute Clinical Trial Management &amp; Real\u2010World Data Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven","family":"Hohenstein","sequence":"additional","affiliation":[{"name":"Helios Health Institute Clinical Trial Management &amp; Real\u2010World Data Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Leiner","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology Heart Center Leipzig at University of Leipzig Leipzig Germany"},{"name":"Helios Health Institute Clinical Trial Management &amp; Real\u2010World Data Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Nitsche","sequence":"additional","affiliation":[{"name":"Helios Health Institute Clinical Trial Management &amp; Real\u2010World Data Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Staudt","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology Helios Hospital Schwerin Schwerin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Steinborn","sequence":"additional","affiliation":[{"name":"Department of Cardiology\/Interventional Electrophysiology Helios Hospital Erfurt Erfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Bietau","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology Helios Hospital Plauen Plauen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henning T.","family":"Baberg","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Nephrology Helios Hospital Berlin\u2010Buch Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Niehaus","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I Helios Hospital Gifhorn Gifhorn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Tebbenjohanns","sequence":"additional","affiliation":[{"name":"Department of Cardiology Helios Hospital Hildesheim Hildesheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melchior","family":"Seyfarth","sequence":"additional","affiliation":[{"name":"Department of Cardiology Helios University Hospital Wuppertal Wuppertal Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus W.","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Helios Dr. Horst Schmidt Kliniken Wiesbaden Clinic of Internal Medicine 1 Wiesbaden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc M.","family":"Vorpahl","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology Helios Hospital Siegburg Siegburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf","family":"Kuhlen","sequence":"additional","affiliation":[{"name":"Fresenius Medical Care AG Bad Homburg v.d. 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