{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T23:40:33Z","timestamp":1790034033131,"version":"4.0.1"},"reference-count":74,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The aim of this paper, which includes a meta\u2010analysis, is to elucidate the effects of cranberry consumption on systolic and diastolic blood pressure based on all relevant randomized controlled trials (RCTs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      A systematic literature search was performed across the ISI Web of Science, PubMed, Embase, the Cochrane Library, and Google Scholar databases, encompassing trials published until December 2024. Weighted mean differences (WMD) were calculated using random or fixed\u2010effects models. Between\u2010study heterogeneity was evaluated using Cochrane's test and the\n                      <jats:italic>I<\/jats:italic>\n                      \u00b2 index. This study's registration number in PROSPERO is CRD420251028424.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 1204 publications were reviewed, leading to the inclusion of 12 trials for qualitative synthesis and meta\u2010analysis. The pooled effect size indicated statistically nonsignificant reductions of 1.31\u2009mmHg for systolic blood pressure (SBP) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.19) and 1.31\u2009mmHg for diastolic blood pressure (DBP) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.12). Stratified analysis showed that the reduction in SBP was statistically significant in studies where cranberry was provided in juice form, with a duration of 8 weeks or less, involving participants with a mean age of &lt;\u200950 years, and predominantly in females. Furthermore, subgroup analysis indicated a significant reduction in DBP in studies that involved both genders, lasted more than 8 weeks, included participants with a normal body mass index, and had a mean age below 50 years.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This systematic review and meta\u2010analysis suggest that cranberry consumption was not effective in managing SBP and DBP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/clc.70254","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T08:33:32Z","timestamp":1776674012000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Effect of Cranberry Consumption on Blood Pressure: A Systematic Review and Meta\u2010Analysis of Randomized Controlled Trials"],"prefix":"10.1002","volume":"49","author":[{"given":"Leyli Zahra","family":"Bahreyni","sequence":"first","affiliation":[{"name":"Student Research Committee, Department of Clinical Nutrition &amp; 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