{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:34:11Z","timestamp":1791916451488,"version":"4.3.4"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the safety, short\u2010term and mid\u2010term occlusion performance of the Absnow fully biodegradable atrial septal occluder in pediatric patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The Absnow Occluder, an innovative fully biodegradable closure for ASD, has shown its safety and effectiveness in initial animal studies and preclinical trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>As one of the participating multicenter research institutions, our organization conducted interventional closure procedures on 10 pediatric patients with atrial septal defects employing the Absnow fully biodegradable occluder between November 2018 and May 2019. Subsequently, we conducted a clinical follow\u2010up spanning 4 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The immediate success rate of the operation was 100% (10\/10). The effective closure rates at immediate, 1 day, 1 month, 3 months, 6 months, 1 year, 2 years, 3 years, and 4 years post\u2010operation were, respectively, 100%, 90%, 100%, 100%, 100%, 100%, 80%, 80%, and 70%. The cumulative incidence of complications at 1 year, 2 years, 3 years, and 4 years post\u2010operation were 0%, 20%, 20%, and 30%, respectively. No severe complications, such as device dislodgment, high\u2010degree atrioventricular block, or vascular complications, occurred during the 4\u2010year follow\u2010up. Nevertheless, two patients experienced substantial residual shunting due to occluder degradation or umbrella displacement, and underwent further intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study further confirmed the short\u2010to\u2010mid\u2010term safety and acceptable efficacy of the Absnow fully biodegradable atrial septal occluder based on a 4\u2010year follow\u2010up. The late\u2010occurring residual shunts with device degradation have an important impact on its long\u2010term efficacy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/clc.70262","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T08:54:22Z","timestamp":1770195262000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Safety and Efficacy of Absnow Fully Biodegradable Atrial Septal Defect Occluder: A Prospective, Single\u2010Center Phase III Clinical Trial"],"prefix":"10.1002","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6491-0237","authenticated-orcid":false,"given":"Shiqiang","family":"Fan","sequence":"first","affiliation":[{"name":"Department of Cardiology Shenzhen Children's Hospital Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shenzhen Children's Hospital Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenheng","family":"Ou","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shenzhen Children's Hospital Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piaohong","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shenzhen Children's Hospital Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shenzhen Children's Hospital Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shenzhen Children's Hospital Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shenzhen Children's Hospital Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boning","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shenzhen Children's Hospital Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1976.03260490024013"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01862-4"},{"issue":"5","key":"e_1_2_10_4_1","first-page":"257","article-title":"Transcatheter Closure of Secundum Atrial Septal Defects","volume":"25","author":"Kazmouz S.","year":"2013","journal-title":"Journal of Invasive Cardiology"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2017.03.073"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2018.01.262"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-017-1613-x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2019.05.073"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.10.066"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2016.02.068"},{"issue":"5","key":"e_1_2_10_11_1","first-page":"521","article-title":"In Vitro Performance Testing of a Novel Bioabsorbable Septal Defect Occluder","volume":"35","author":"Xie Z. F.","year":"2016","journal-title":"Beijing Biomedical Engineering"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000446313"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.27852"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.120851"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.28529"},{"key":"e_1_2_10_16_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2021\/6369493","article-title":"Initial Clinical Experience With the Biodegradable AbsnowTM Device for Percutaneous Closure of Atrial Septal Defect: A 3\u2010Year Follow\u2010up","volume":"2021","author":"Li Y.","year":"2021","journal-title":"Journal of Interventional Cardiology"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.1999.1909"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.88.2.621"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.28814"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.664672"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.25783"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-17-00006"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.2478\/v10019-012-0029-8"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.22735"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/735989"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/joic.12550"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjy012"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym15010108"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.2172"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.70262","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/clc.70262","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.70262","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:28:18Z","timestamp":1773008898000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.70262"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/clc.70262"],"URL":"https:\/\/doi.org\/10.1002\/clc.70262","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"2024-07-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70262"}}