{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T19:30:39Z","timestamp":1786476639843,"version":"build-2736575974"},"reference-count":13,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to evaluate the prognostic value of the hemoglobin\u2013albumin\u2013lymphocyte\u2013platelet (HALP) score in patients with rheumatic mitral stenosis (RMS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 169 patients with RMS were retrospectively analyzed over a median follow\u2010up period of 124 months (IQR: 96\u2013148). The primary endpoint was major adverse cardiac and cerebrovascular events (MACCE). The predictive performance of the HALP score was assessed using receiver operating characteristic (ROC) analysis, Cox regression, and Kaplan\u2013Meier survival analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The HALP score demonstrated a modest but statistically significant ability to predict MACCE (AUC\u2009=\u20090.644,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.037). The optimal cut\u2010off value was 35.65, with a sensitivity of 60.4% and specificity of 38.1%. Patients with lower HALP scores had a significantly higher incidence of MACCE (log\u2010rank\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.015). However, in multivariable analysis, the HALP score was not identified as an independent predictor (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.076).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The HALP score may serve as a simple and cost\u2010effective complementary tool for risk stratification in patients with RMS. However, its prognostic value appears limited when used alone, and it should be interpreted alongside established clinical and echocardiographic parameters.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/clc.70287","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T11:17:14Z","timestamp":1774610234000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Prognostic Value of HALP Score in Rheumatic Mitral Stenosis: A Long\u2010Term Follow\u2010up Study"],"prefix":"10.1002","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0544-0657","authenticated-orcid":false,"given":"Ahmet Ferhat","family":"Kaya","sequence":"first","affiliation":[{"name":"Department of Cardiology Van Regional Education and Research Hospital Van Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6rkem","family":"Ayhan","sequence":"additional","affiliation":[{"name":"Department of Cardiology Van Regional Education and Research Hospital Van Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veysi","family":"Can","sequence":"additional","affiliation":[{"name":"Department of Cardiology Van Regional Education and Research Hospital Van Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emrah","family":"\u00d6zbek","sequence":"additional","affiliation":[{"name":"Department of Cardiology Van Regional Education and Research Hospital Van Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lezgin","family":"Dursun","sequence":"additional","affiliation":[{"name":"Department of Cardiology Bing\u00f6l State Hospital Bing\u00f6l Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5369-5414","authenticated-orcid":false,"given":"\u00d6mer","family":"K\u00fcmet","sequence":"additional","affiliation":[{"name":"Department of Cardiology Van Regional Education and Research Hospital Van Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,27]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.13.3.470"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1586\/14779072.3.3.345"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2023.1241217"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0000000000002506"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61171-9"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.10.003"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.11574"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.13600"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-025-04968-2"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.123.016302"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.5152\/akd.2013.4643"},{"issue":"1","key":"e_1_2_11_13_1","first-page":"30","article-title":"Neutrophil\u2010to\u2010Lymphocyte Ratio as a Predictor of Severity in Patients With Rheumatic Mitral Valve Stenosis","volume":"6","author":"Rambe A. S.","year":"2023","journal-title":"Journal of Society Medicine"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.14744\/ejmi.2017.37275"}],"updated-by":[{"DOI":"10.1002\/clc.70361","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000}}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.70287","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/clc.70287","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.70287","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T19:05:30Z","timestamp":1786475130000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.70287"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,27]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/clc.70287"],"URL":"https:\/\/doi.org\/10.1002\/clc.70287","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,27]]},"assertion":[{"value":"2025-09-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70287"}}