{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T19:30:54Z","timestamp":1786476654961,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Rare occurrence, immune checkpoint inhibitors (ICI)\u2010related myocarditis are poorly documented in the literature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Research Design and Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective review of patients who had ICI until June 2023. Patient follow\u2010up was extended until death or on May 2024. The primary outcome was the incidence of suspected ICI\u2010related myocarditis. Logistic regression was used to investigate the associations between clinical characteristics and suspected ICI\u2010related myocarditis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the included 8199 patients, 1638 (19.98%) patients developed suspected ICI\u2010related myocarditis. Logistic regression revealed that thymomas and thymic carcinomas (OR 2.242; [95% CI, 1.132\u20134.440],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.021), lung cancer (OR 1.259; [95% CI, 1.119\u20131.416],\n                      <jats:italic>p\u2009<\/jats:italic>\n                      &lt;\u20090.001), older patients (OR 1.021; [95% CI, 1.016\u20131.026],\n                      <jats:italic>p\u2009<\/jats:italic>\n                      &lt;\u20090.001), male (OR 1.213; [95% CI, 1.061\u20131.388],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005), block two or more immune checkpoints (OR\u2009=\u20091.391 [95% CI 1.058\u20131.828],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.018), combined with hypertension (OR\u2009=\u20091.326 [95% CI 1.162\u20131.513],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), or hyperlipidemia (OR\u2009=\u20091.656 [95% CI 1.302\u20132.107],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) were associated with higher risk of suspected ICI\u2010related myocarditis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This large, real\u2010world cohort demonstrates that the incidence of suspected ICI\u2010related myocarditis may be underestimated in previous literature. Routine cardiac surveillance is needed in high\u2010risk patients receiving ICI therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      Registered at\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.chictr.org.cn\">https:\/\/www.chictr.org.cn<\/jats:ext-link>\n                      (identifier: ChiCTR2300075974).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/clc.70312","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T13:11:35Z","timestamp":1776690695000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical Characteristics and Risk Factors of Immune Checkpoint Inhibitor\u2010Related Myocarditis: A Real World Observational Study"],"prefix":"10.1002","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0226-3480","authenticated-orcid":false,"given":"Mei","family":"Zhan","sequence":"first","affiliation":[{"name":"Department of Pharmacy, West China Hospital Sichuan University Chengdu Sichuan China"},{"name":"West China School of Pharmacy Sichuan University Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinran","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, West China Hospital Sichuan University Chengdu Sichuan China"},{"name":"West China School of Pharmacy Sichuan University Chengdu Sichuan China"},{"name":"Department of Pharmacy, Institute of Metabolic Diseases and Pharmacotherapy, West China Hospital Sichuan University Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Liu","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Medical 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