{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T11:19:36Z","timestamp":1783163976011,"version":"3.54.6"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100006520","name":"Edwards Lifesciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006520","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Aortic valve replacement (AVR) with the INSPIRIS RESILIA aortic valve (Edwards Lifesciences, Irvine, CA) has established durability and promising outcomes. However, real\u2010world safety and functional performance data remain limited. This study reported early outcomes in the Chinese population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective, multicenter, single\u2010arm, post\u2010market, real\u2010world study enrolled patients scheduled for elective AVR using the study valve. Safety outcomes included all\u2010cause death, study valve\u2010related death, structural valve deterioration (SVD), non SVD, reoperation on the study valve, major bleeding, and thromboembolic events. Effectiveness outcomes included valve hemodynamic performance and New York Heart Association (NYHA) class.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 250 patients underwent study valve implantation, with 238 completing 1\u2010year follow\u2010up (mean follow\u2010up duration: 448.2\u2009\u00b1\u2009162.50 days). The mean age was 58.5\u2009\u00b1\u20099.17 years, with 11.4% undergoing concomitant aortic root\/annular enlargement. The 1\u2010year freedom from all\u2010cause death and freedom from reoperation on the study valve were 98.0% and 99.2%, respectively. All deaths were assessed as unrelated to the study device. Incidence of complications included thromboembolic events (2.4%), major bleeding (4.4%), endocarditis (0.4%), and new permanent pacemaker implantation (0.4%) at 1 year. Two patients (0.8%) required reoperation on the study valve. No SVD was observed. At 1\u2010year post\u2010operation, no severe aortic regurgitation (AR) occurred, while 1 patient (0.4%) developed moderate AR. Three patients (1.3%) had mild paravalvular leakage. Functional status improved with 100% of patients having a NYHA Class I\/II at 1 year.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>INSPIRIS RESILIA aortic valve shows favorable 1\u2010year safety profiles and stable hemodynamics in Chinese patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/clc.70347","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T17:09:17Z","timestamp":1781543357000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Early Outcomes of Real\u2010World Aortic Valve Replacement With RESILIA Tissue in the Chinese Population"],"prefix":"10.1002","volume":"49","author":[{"given":"Haitao","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7167-0261","authenticated-orcid":false,"given":"Yang","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery The First Affiliated Hospital of Xi'an Jiaotong University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Nanjing First Hospital Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3656-2916","authenticated-orcid":false,"given":"Jiangang","family":"Wang","sequence":"additional","affiliation":[{"name":"Valve and Atrial Fibrillation Surgery Center, Beijing Anzhen Hospital, Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hansong","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,15]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-021-00570-z"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12062178"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.124.037991"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.26599\/1671-5411.2024.09.008"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2025.1512961"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2004.06.033"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2018.4045"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx199"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/17434440.2021.1886921"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xjon.2021.10.056"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atssr.2024.11.013"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2021.12.058"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xjon.2025.101557"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2023.09.047"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.4244\/AIJ-D-23-00049"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000001863"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2013.01.083"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000932"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2007.12.082"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezx158"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivad115"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.03.014"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1700456"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.04.049"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.030525"},{"key":"e_1_2_11_27_1","first-page":"159","article-title":"Bioprosthetic Valve Size Selection to Optimize Aortic Valve Replacement Surgical Outcome: A Fluid\u2010Structure Interaction Modeling Study","volume":"127","author":"Li C.","year":"2020","journal-title":"CMES \u2010 Comp Model Eng Sci"},{"key":"e_1_2_11_28_1","volume-title":"StatPearls. 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