{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T11:19:50Z","timestamp":1783163990878,"version":"3.54.6"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Whether sedentary behavior and physical activity causally influence hypertension remains uncertain. We used Mendelian randomization (MR) to examine whether genetically predicted domain\u2010specific sedentary behaviors and leisure\u2010time physical activity are associated with hypertension risk and to explore potential cardiometabolic pathways.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a two\u2010sample MR using genome\u2010wide significant, LD\u2010independent SNPs as instruments for domain\u2010specific sedentary traits and physical activity. Hypertension was defined by the FinnGen R9 endpoint I9_HYPTENSESS. Pleiotropy\u2010robust estimators, outlier procedures and two\u2010step MR mediation analyses were applied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Genetically proxied leisure screen time (LST) was associated with a higher risk of hypertension (IVW OR\u2009=\u20091.181, 95% CI 1.076\u20131.296,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20094.70e\n                      <jats:sup>\u22124<\/jats:sup>\n                      ). Two\u2010step MR suggested that body mass index (BMI) and type 2 diabetes (T2D) may partly account for this association, with estimated mediated proportions of 54.7% and 14.7%, respectively, although these estimates should be interpreted cautiously. No robust associations were observed for moderate\u2010to\u2010vigorous physical activity (MVPA) or sedentary behavior at work (SDW). The MVPA estimate was directionally protective, but these null findings remained inconclusive given lower instrument informativeness.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Genetically proxied LST was associated with higher hypertension risk and may represent a plausible, potentially actionable prevention target. BMI and T2D may partly account for this association. No robust associations were observed for MVPA or SDW, but these null findings should not be interpreted as definitive evidence of no effect. Further validation in prospective, multi\u2010ancestry, and mechanistic studies is needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/clc.70380","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T17:19:04Z","timestamp":1781543944000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sedentary Behavior, Physical Activity, and Hypertension: Genetic Liability and the Role of Metabolic Factors"],"prefix":"10.1002","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2478-2943","authenticated-orcid":false,"given":"Ye","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Cardiology, Renmin Hospital Hubei University of Medicine Shiyan Hubei P. R. China"},{"name":"Hubei Clinical Medical Research Center for Atherosclerotic Cardiovascular Diseases Hubei University of Medicine Shiyan Hubei Province P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Renmin Hospital Hubei University of Medicine Shiyan Hubei P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Renmin Hospital Hubei University of Medicine Shiyan Hubei P. R. China"},{"name":"Hubei Clinical Medical Research Center for Atherosclerotic Cardiovascular Diseases Hubei University of Medicine Shiyan Hubei Province P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Renmin Hospital Hubei University of Medicine Shiyan Hubei P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Renmin Hospital Hubei University of Medicine Shiyan Hubei P. R. China"},{"name":"Hubei Clinical Medical Research Center for Atherosclerotic Cardiovascular Diseases Hubei University of Medicine Shiyan Hubei Province P. R. 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