{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T11:20:50Z","timestamp":1783164050561,"version":"3.54.6"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic kidney disease (CKD) is prevalent among patients undergoing percutaneous coronary intervention (PCI) and associated with adverse cardiovascular outcomes. This study evaluated the association between moderate\u2010to\u2010severe CKD and major adverse cardiovascular events (MACE) after drug\u2010eluting stent (DES) implantation using propensity score matching.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective cohort study included 200 patients undergoing PCI with DES implantation (January 2020 to January 2025). Patients were stratified by baseline eGFR: non\u2010CKD\/mild CKD (\u2265\u200960\u2009mL\/min\/1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      ); and moderate\u2010to\u2010severe CKD (&lt;\u200960\u2009mL\/min\/1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      ). After 1:1 propensity score matching, 55 pairs were analyzed. The primary endpoint was MACE, defined as all\u2010cause death, myocardial infarction, stroke, or ischemia\u2010driven repeat revascularization.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After matching, patients with moderate\u2010to\u2010severe CKD had lower MACE\u2010free survival (log\u2010rank\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003). Cox regression with robust sandwich standard errors clustered by matched pair showed that moderate\u2010to\u2010severe CKD was independently associated with higher MACE risk (HR 3.20, 95% CI 1.36\u20137.53;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008). Renal function deterioration (eGFR decline\u2009\u2265\u200930%) occurred more frequently in the CKD group (20.0% vs. 3.6%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.028). Higher rates of BARC type 2\u20135 bleeding and contrast\u2010associated AKI were observed in the CKD group; contrast\u2010associated AKI reached statistical significance in the matched analysis (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.030). Sensitivity analysis using inverse probability of treatment weighting supported the robustness of these findings (MACE:\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Moderate\u2010to\u2010severe CKD was independently associated with a higher risk of MACE and renal deterioration after DES implantation. These findings support incorporating CKD severity into post\u2010PCI risk stratification and highlight the potential value of integrated cardiorenal monitoring and individualized management in this high\u2010risk population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/clc.70387","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T10:14:29Z","timestamp":1781864069000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Chronic Kidney Disease Severity on Clinical Outcomes After Drug\u2010Eluting Stent Implantation: A Propensity Score\u2013Matched Analysis"],"prefix":"10.1002","volume":"49","author":[{"given":"Hongxu","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Cardiology Beijing Haidian Hospital Beijing 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