{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T18:01:38Z","timestamp":1785175298070,"version":"3.55.0"},"reference-count":42,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Left bundle branch block (LBBB) is a well\u2010established predictor of response to cardiac resynchronization therapy (CRT) in heart failure with reduced ejection fraction. However, several electrocardiographic definitions are used, and their relative significance remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis<\/jats:title>\n                    <jats:p>Stricter electrocardiographic definitions of LBBB are associated with improved response to CRT and more favorable clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective single\u2010center cohort study including 109 patients who underwent CRT\u2010defibrillator implantation. Baseline electrocardiograms were classified according to six commonly used LBBB definitions. The primary endpoint was echocardiographic response at 6 months, defined as a\u2009\u2265\u200910% absolute increase in left ventricular ejection fraction or a\u2009\u2265\u200915% reduction in left ventricular end\u2010systolic volume. Secondary endpoints included heart failure hospitalization and all\u2010cause mortality. Multivariable logistic, Cox, and negative binomial regression models were used, with odds ratios (OR), hazard ratios (HR), incidence rate ratios (IRR), and 95% confidence intervals (CI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Strauss\u2010defined LBBB was independently associated with echocardiographic response (adjusted OR, 7.47; 95% CI, 2.52\u201325.0;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and showed the highest discriminative performance (area under the curve, 0.728; 95% CI, 0.643\u20130.814). Strauss was also associated with lower heart failure hospitalization rates (adjusted IRR, 0.30; 95% CI, 0.13\u20130.64;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002) and reduced mortality (adjusted HR, 0.14; 95% CI, 0.02\u20130.99;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.049). Median follow\u2010up was 30 months (IQR 14\u201360).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Different LBBB definitions are associated with differences in CRT response and outcomes. Stricter criteria appear to better identify patients more likely to respond, with more favorable outcomes. These findings may help refine patient selection for CRT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/clc.70408","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T14:03:47Z","timestamp":1783346627000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Strauss\u2010Defined LBBB Identifies Patients With Improved Outcomes After CRT\u2010D: A Comparative Cohort Study"],"prefix":"10.1002","volume":"49","author":[{"given":"Athanasios","family":"Saplaouras","sequence":"first","affiliation":[{"name":"Department of Cardiology Onassis Hospital Athens Greece"},{"name":"Aristotle University of Thessaloniki Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5411-6461","authenticated-orcid":false,"given":"Konstantinos","family":"Pamporis","sequence":"additional","affiliation":[{"name":"Aristotle University of 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Onassis Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athena","family":"Batsouli","sequence":"additional","affiliation":[{"name":"Department of Cardiology Evaggelismos Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9162-6039","authenticated-orcid":false,"given":"Ourania","family":"Kariki","sequence":"additional","affiliation":[{"name":"Department of Cardiology Onassis Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1009-9772","authenticated-orcid":false,"given":"George","family":"Bazoukis","sequence":"additional","affiliation":[{"name":"Department of Cardiology Larnaca General Hospital Larnaca Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sotirios","family":"Xydonas","sequence":"additional","affiliation":[{"name":"Department of Cardiology Larnaca General Hospital Larnaca 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