{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T18:01:29Z","timestamp":1785175289870,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:00:00Z","timestamp":1784332800000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acute myocardial infarction (AMI) with essential hypertension (EH) and secondary hypertension (SH) remains a leading cause of mortality. Despite the overall decline, disparities in mortality trends across age group, gender, urbanization, racial, and regional subgroups remain underexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Mortality data from the CDC WONDER (2000\u20132024) were analyzed for AMI (ICD\u201010 I21) as the primary cause of death and EH (ICD\u201010 I10) and SH (ICD\u201010 I15.0, I15.9) as a contributing factor in individuals aged \u2265\u200925 years. Age\u2010adjusted mortality rates (AAMRs) were standardized to the US 2000 population. Joinpoint regression estimated annual percentage changes (APCs) with 95% confidence intervals (CIs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      AMI with hypertension caused 842,646 deaths, with AAMR declining from 17.63 in 2000 to 12.26 in 2024. Overall, the AAMR showed a significant decline across the study period (AAPC: \u22121.71%). Males consistently had a higher mean AAMR (18.50) than females (11.82). Upward inflections were noted in the South region during 2018\u20132021 (APC: 11.17%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004), Non\u2010Hispanic Black individuals during 2018\u20132021 (APC: 9.45%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.053), metropolitan areas during 2018\u20132020 (APC: 7.71%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.038), and among adults aged 65\u201374 years during 2018\u20132021 (APC: 7.15%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.039). State\u2010level variations were observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Despite the overall decline, rising mortality trends were observed in the Southern region (2018\u20132021), metropolitan areas, and among individuals aged 65\u201374 years, highlighting emerging patterns and emphasizing the need for targeted interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/clc.70420","type":"journal-article","created":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T10:31:29Z","timestamp":1784370689000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Epidemiological Trends in Mortality From Acute Myocardial Infarction With Essential and Secondary Hypertension: CDC WONDER Database Analysis, 2000\u20132024"],"prefix":"10.1002","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8587-7168","authenticated-orcid":false,"given":"Javeria","family":"Akhter","sequence":"first","affiliation":[{"name":"Indus Hospital and Health Network  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9351-0520","authenticated-orcid":false,"given":"Waleed","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Lahore Medical and Dental College  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3028-1757","authenticated-orcid":false,"given":"Aasiya","family":"Shahbaz","sequence":"additional","affiliation":[{"name":"Dow University of Health Sciences  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5501-2351","authenticated-orcid":false,"given":"Aniqa","family":"Dejwani","sequence":"additional","affiliation":[{"name":"Dow University of Health Sciences  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9538-8051","authenticated-orcid":false,"given":"Nafila","family":"Zeeshan","sequence":"additional","affiliation":[{"name":"Dow University of Health Sciences  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2651-9827","authenticated-orcid":false,"given":"Jamil","family":"Nasrallah","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medical Sciences Lebanese University  Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,18]]},"reference":[{"key":"e_1_2_14_2_1","volume-title":"Statpearls","author":"Mechanic O. 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