{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T18:01:25Z","timestamp":1785175285847,"version":"3.55.0"},"reference-count":43,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Inflammation and thrombosis influence short\u2010term outcomes after primary percutaneous coronary intervention (PCI) for acute ST\u2010segment elevation myocardial infarction (STEMI). The platelet\u2010to\u2010lymphocyte ratio (PLR) is an inexpensive marker that may support bedside risk stratification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess whether pre\u2010PCI and post\u2010PCI PLR predict in\u2010hospital outcomes and 90\u2010day all\u2010cause mortality in STEMI patients undergoing primary PCI in Palestine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study included STEMI patients referred for primary PCI at An\u2010Najah National University Hospital. Of 413 eligible patients, 118 were excluded for incomplete records, leaving 295 patients for analysis. PLR was measured before and after PCI and dichotomized using ROC\u2010derived cutoffs: pre\u2010PCI PLR\u2009&lt;\u200921.68 versus \u2265\u200921.68 and post\u2010PCI PLR\u2009&lt;\u200914.85 versus \u2265\u200914.85. Outcomes were compared between groups, and multivariable logistic regression was used to assess independent associations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Elevated pre\u2010PCI PLR was associated with greater in\u2010hospital clinical instability and remained independently associated with the composite in\u2010hospital clinical endpoint, both per 10\u2010unit increase (OR 1.41, 95% CI 1.13\u20131.74;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002) and using the cutoff \u2265\u200921.68 (OR 2.90, 95% CI 1.55\u20135.44;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). However, pre\u2010PCI PLR was not independently associated with heart failure or 90\u2010day mortality. Post\u2010PCI PLR showed stronger prognostic value and was independently associated with composite in\u2010hospital events, heart failure, and 90\u2010day mortality, both as a continuous variable and using the cutoff \u2265\u200914.85.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Post\u2010PCI PLR demonstrated stronger prognostic value than pre\u2010PCI PLR and may serve as a simple, low\u2010cost adjunctive marker for short\u2010term risk stratification after primary PCI in STEMI patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/clc.70422","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T10:05:17Z","timestamp":1785146717000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Predictive Value of Platelet\u2010to\u2010Lymphocyte Ratio Before and After Percutaneous Coronary Intervention in Patients With Acute ST\u2010Segment Elevation Myocardial Infarction: A Retrospective Cohort Study in Palestine"],"prefix":"10.1002","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7767-6573","authenticated-orcid":false,"given":"Anwar","family":"Zahran","sequence":"first","affiliation":[{"name":"Department of Medicine, Faculty of Medicine and Allied Medical Sciences An\u2010Najah National University Nablus Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3454-9988","authenticated-orcid":false,"given":"Saja","family":"Amer","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine and Allied Medical Sciences An\u2010Najah National University Nablus Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8968-7034","authenticated-orcid":false,"given":"Mohammad","family":"Bdair","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine and Allied Medical Sciences An\u2010Najah National University Nablus Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seema","family":"Hameedi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine and Allied Medical Sciences An\u2010Najah National University Nablus Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roa","family":"Badran","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine and Allied Medical Sciences An\u2010Najah National University Nablus Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mays","family":"Safa","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine and Allied Medical Sciences An\u2010Najah National University Nablus Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6734-8341","authenticated-orcid":false,"given":"Abdelfattah M.","family":"Dahmas","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine and Allied Medical Sciences An\u2010Najah National University Nablus Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Mohammad","sequence":"additional","affiliation":[{"name":"Hurley Medical Center\u2010MSU Flint Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul\u2010rahman","family":"Abdel\u2010karim","sequence":"additional","affiliation":[{"name":"An\u2010Najah National University 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