{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T07:56:20Z","timestamp":1790582180949,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170322"],"award-info":[{"award-number":["82170322"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Transition zone (TZ) may serve as a potential substrate for atrial fibrillation (AF). This study aims to investigate the relationship of TZ burden with left atrial conduction velocity (LACV) and recurrence after circumferential pulmonary vein isolation (CPVI) in elderly patients with paroxysmal AF without low\u2010voltage areas (LVA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with paroxysmal AF without LVA were categorized into three groups based on the TZ burden (&lt;\u20095%, 5%\u201315% and &gt;\u200915%). TZs were defined as regions with bipolar voltage between 0.5 and 1\u2009mV in more than 3 adjacent points. TZ burden was calculated as the proportion of TZ on the entire left atrium surface. LACV were calculated as conduction distance divided by conduction time. Recurrence was defined as any episode of atrial tachyarrhythmia (ATA) lasting \u2265\u200930\u2009s after a 3\u2010month blanking period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the 158 enrolled patients (mean age 69.7\u2009\u00b1\u20093.8 years), 48 (30.4%) had a TZ\u2009&lt;\u20095%, 66 (41.8%) had a TZ of 5%\u201315%, and 44 (27.8%) had a TZ\u2009&gt;\u200915%. Patients with higher TZ burden exhibited significantly decreased anterior LACV (1.52\u2009\u00b1\u20090.36 vs. 1.21\u2009\u00b1\u20090.27 vs. 1.02\u2009\u00b1\u20090.25\u2009m\/s,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). After a mean follow\u2010up of 24.9 months, 40 (25.3%) patients experienced recurrence. Patients with recurrence had higher TZ burden (15.4 [7.2\u201322.4] vs. 8.2 [3.5\u201314.3],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). TZ burden remained significantly associated with recurrence in a multivariable Cox regression model (adjusted HR 1.065 [95% CI 1.034\u20131.098],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>TZ burden is correlated with slow LACV and independently predicts ATA recurrence following CPVI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/clc.70435","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T05:05:33Z","timestamp":1788239133000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of Transition Zone Burden With Recurrence in Elderly Patients With Paroxysmal Atrial Fibrillation Without Low\u2010Voltage Areas"],"prefix":"10.1002","volume":"49","author":[{"given":"Yuxuan","family":"Wang","sequence":"first","affiliation":[{"name":"Division of Cardiology The First Affiliated Hospital with Nanjing Medical University Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Qiu","sequence":"additional","affiliation":[{"name":"Division of Cardiology The First Affiliated Hospital with Nanjing Medical University Nanjing Jiangsu China"},{"name":"Division of Cardiology The Affiliated Taizhou People's Hospital of Nanjing Medical University Taizhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haojun","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Cardiology The First Affiliated Hospital with Nanjing Medical University Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Cui","sequence":"additional","affiliation":[{"name":"Division of 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