{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T22:27:56Z","timestamp":1791066476185,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      No\u2010reflow phenomenon (NRP) frequently complicates ST\u2010elevation myocardial infarction (STEMI). This study evaluated the CHA\n                      <jats:sub>2<\/jats:sub>\n                      DS\n                      <jats:sub>2<\/jats:sub>\n                      \u2010VA score (CV score) as a predictor of NRP in STEMI patients undergoing primary PCI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 725 STEMI patients were retrospectively enrolled and stratified by median of CV score (\u2264\u20092 vs. &gt;\u20092). The predictive ability of the CV score for NRP was assessed using logistic regression, receiver operating characteristic analysis, and DeLong tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      NRP incidence was higher in the high CV score group (15.2% vs. 8.7%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007). The CV score predicted NRP overall (adjusted OR: 1.295,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002), but this effect was confined to females (AOR: 1.597,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002), with no significant association in males. Area under the curve value (AUC) of the CV score for predicting NRP was 0.613 in all patients (38.8% sensitivity and 79.1% specificity,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) and 0.673 in females (78.1% sensitivity and 47.6% specificity,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002). A significant sex \u00d7 CV score interaction (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.017) confirmed sex\u2010modified predictive value. DeLong tests combining the CV score with laboratory markers improved prediction in males but not females.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The CV score is a sex\u2010specific predictor of NRP in STEMI, with predictive value in females but not males. These findings support a tailored risk stratification approach: using the CV score alone for female patients, while integrating laboratory and procedural markers for male patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/clc.70439","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T10:34:09Z","timestamp":1785926049000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Predictive Ability of the CHA\n                    <sub>2<\/sub>\n                    DS\n                    <sub>2<\/sub>\n                    \u2010VA Score for No\u2010Reflow Phenomenon in ST\u2010Elevation Myocardial Infarction Patients Undergoing Primary PCI"],"prefix":"10.1002","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0826-8338","authenticated-orcid":false,"given":"Ying","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Cardiology Liaocheng People's Hospital Affiliated to Shandong First Medical University Liaocheng Shandong People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Cardiology Liaocheng People's Hospital Affiliated to Shandong First Medical University Liaocheng Shandong People's Republic of China"},{"name":"Department of Cardiology, Liaocheng Dongchangfu People's Hospital Liaocheng People's Hospital Dongchangfu Campus Liaocheng Shandong People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Liaocheng People's Hospital Affiliated to Shandong First Medical University Liaocheng Shandong People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunsong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Liaocheng People's Hospital Affiliated to Shandong First Medical University Liaocheng Shandong People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Liaocheng People's Hospital Affiliated to Shandong First Medical University Liaocheng Shandong People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Liaocheng People's Hospital Affiliated to Shandong First Medical University Liaocheng Shandong People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuewen","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Liaocheng People's Hospital Affiliated to Shandong First Medical University Liaocheng Shandong People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0291-8723","authenticated-orcid":false,"given":"Hengchen","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Cardiology Liaocheng People's Hospital Affiliated to Shandong First Medical University Liaocheng Shandong People's Republic of China"},{"name":"Liaocheng People's Hospital Shandong University Jinan Shandong People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.06.025"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11082233"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12175592"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9092956"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/anec.12811"},{"issue":"47","key":"e_1_2_10_7_1","first-page":"168","article-title":"Ischemic Changes in Lead aVR Is Associated With Left Ventricular Thrombus or High\u2010Grade Spontaneous Echocontrast in Patients With Acute Anterior Myocardial Infarction","volume":"2019","author":"\u0130\u00e7en Y. 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