{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:28:49Z","timestamp":1787754529384,"version":"build-2784847793"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>No direct head\u2010to\u2010head trials compare tirzepatide and dulaglutide in heart failure with preserved ejection fraction (HFpEF), though tirzepatide shows superior weight loss and potential cardiovascular benefits in recent trials like SURPASS\u2010CVOT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective, propensity score\u2010matched cohort study used de\u2010identified electronic health records from the TriNetX US Collaborative Network (as of December 2025). Adults \u2265 18 years with HFpEF (ICD\u201010: I50.3) initiating tirzepatide (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200935\u2009174) or dulaglutide (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200952\u2009999), without prior exposure to the comparator, were identified. One\u2010to\u2010one greedy nearest\u2010neighbor matching (caliper 0.1) on demographics, comorbidities, medications, and laboratory\/echocardiographic data produced balanced cohorts of 24\u2009305 patients each. Kaplan\u2013Meier and Cox proportional hazards models evaluated 1\u2010year and 3\u2010year risks of all\u2010cause mortality, acute heart failure events, all\u2010cause hospitalization, myocardial infarction, stroke, atrial fibrillation, MACE, MAKE, acute pancreatitis, and hypoglycemia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Post\u2010matching, cohorts were well\u2010balanced. Tirzepatide linked to lower 1\u2010year risks of all\u2010cause mortality (HR: 0.66, 95% CI: [0.59\u20130.74]), all\u2010cause hospitalization (HR: 0.85, 95% CI: [0.82\u20130.88]), stroke (HR: 0.92, 95% CI: [0.87\u20130.97]), MACE (HR: 0.89, 95% [CI: 0.84\u20130.93]), MAKE (HR: 0.85, 95% CI: [0.79\u20130.91]), and acute pancreatitis (HR: 0.78, 95% CI: [0.63\u20130.96]). Benefits amplified at 3 years, especially mortality (HR: 0.60, [0.55\u20130.65]). Tirzepatide showed slightly higher 1\u2010year atrial fibrillation risk (HR: 1.04, [1.00\u20131.07]). No differences in myocardial infarction or hypoglycemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this large real\u2010world propensity\u2010matched analysis, tirzepatide demonstrated superior reductions in mortality, hospitalizations, and cardiorenal outcomes versus dulaglutide in HFpEF patients, with a favorable safety profile.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/clc.70441","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T10:56:39Z","timestamp":1786359399000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Superior Cardiorenal Protection With Tirzepatide Over Dulaglutide in Heart Failure With Preserved Ejection Fraction: A Large\u2010Scale Propensity Score\u2013Matched Real\u2010World Analysis"],"prefix":"10.1002","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8995-1058","authenticated-orcid":false,"given":"Ibrahim","family":"Khalil","sequence":"first","affiliation":[{"name":"Dhaka Medical College and Hospital Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3949-9388","authenticated-orcid":false,"given":"Md. Imran","family":"Hossain","sequence":"additional","affiliation":[{"name":"Manikganj Medical College and Hospital Manikganj Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mst. Mahmuda","family":"Akter","sequence":"additional","affiliation":[{"name":"Manikganj Medical College and Hospital Manikganj Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7970-4364","authenticated-orcid":false,"given":"Ferdous","family":"Wahid","sequence":"additional","affiliation":[{"name":"Dinajpur Medical College and Hospital Dinajpur Rangpur Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4937-5500","authenticated-orcid":false,"given":"Aizaz Anwar","family":"Khalid","sequence":"additional","affiliation":[{"name":"Peshawar Medical College Peshawar Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunjida Amin","family":"Promi","sequence":"additional","affiliation":[{"name":"Chattogram Medical College and Hospital Chattogram Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4671-8490","authenticated-orcid":false,"given":"Md. Abu","family":"Sayed","sequence":"additional","affiliation":[{"name":"Chattogram Medical College and Hospital Chattogram Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd Turzo","family":"Rahman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Flushing Hospital Medical Center New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pallab","family":"Sarker","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Reading Hospital West Reading Pennsylvania 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