{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:29:11Z","timestamp":1787754551199,"version":"build-2784847793"},"reference-count":51,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ischemic heart disease (IHD) remains a leading cause of mortality in the United States, while arrhythmia\u2010related deaths are increasing. However, long\u2010term mortality trends involving both conditions remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We utilized the CDC WONDER Multiple Cause\u2010of\u2010Death database to obtain records from 1999 to 2023, targeting US adults aged \u2265\u200925 years. Deaths involving IHD and arrhythmias were assessed. Age\u2010adjusted mortality rates (AAMR) were calculated and stratified by gender, age, ethnicity, census region, and urbanization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 1\u2009795\u2009918 deaths were attributed to both IHD and cardiac arrhythmias between 1999 and 2023. The AAMR declined from 41.97 (95% CI: 41.66\u221242.27) in 1999 to 32.73 (95% CI: 32.51\u221232.94) in 2023, representing an overall decrease of 22% (AAPC \u22120.99). Men had higher AAMRs compared to women (45.0 [95% CI: 44.6\u221245.5] vs. 23.4 [95% CI: 23.2\u221223.7]). The highest mortality rate was observed among NH White individuals (AAMR: 34.8; 95% CI: 34.5\u221235.0), while the lowest was among NH Asian or Pacific Islanders (AAMR: 16.5; 95% CI: 15.6\u221217.5). Older adults exhibited the higher AAMRs (144.74; 95% CI: 143.60\u2212145.88) compared to younger cohorts. An increased death burden was observed in non\u2010metropolitan (AAMR: 37.1; 95% CI: 36.5\u221237.8) and Midwest regions (35.5; 95% CI: 34.9\u221236.0). The majority of the deaths occurred in inpatient facilities (34.7%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Although IHD\u2013arrhythmia mortality declined between 1999 and 2023, substantial disparities persisted across demographic and geographic subgroups, highlighting the need for targeted public health interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/clc.70450","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T12:08:51Z","timestamp":1786709331000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Temporal Trends in Mortality Due to Ischemic Heart Disease and Cardiac Arrhythmias in the United States From 1999 to 2023"],"prefix":"10.1002","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1214-4258","authenticated-orcid":false,"given":"Taha","family":"Alam","sequence":"first","affiliation":[{"name":"Dow Medical College Dow University of Health Sciences Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9914-7636","authenticated-orcid":false,"given":"Sohaima","family":"Kamal","sequence":"additional","affiliation":[{"name":"Dow Medical College Dow University of Health Sciences Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7427-5687","authenticated-orcid":false,"given":"Dhvanit","family":"Rajdeep","sequence":"additional","affiliation":[{"name":"Department of Medicine Caucasus International University Tbilisi Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6882-2195","authenticated-orcid":false,"given":"F. 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U.","family":"Areesha","sequence":"additional","affiliation":[{"name":"Dow Medical College Dow University of Health Sciences Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7130-850X","authenticated-orcid":false,"given":"Pardeep","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Medicine Liaquat University of Medical and Health Sciences Jamshoro Sindh Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6275-0981","authenticated-orcid":false,"given":"Hamza Yousuf","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Deparment of Medicine Jinnah Medical and Dental College Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5863-0386","authenticated-orcid":false,"given":"Muhammad Suleman","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Medicine Pakistan Naval Ship (PNS) Shifa Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8157-1037","authenticated-orcid":false,"given":"Muhammad Ibrahim","family":"Rashid","sequence":"additional","affiliation":[{"name":"Department of Medicine Bahria University College of Medicine, Bahria University Islamabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2779-7211","authenticated-orcid":false,"given":"Alisha","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Medicine Jinnah Sindh Medical University Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6359-7133","authenticated-orcid":false,"given":"Muhammad Raafay","family":"Jamil","sequence":"additional","affiliation":[{"name":"Department of Medicine Quaid\u2010e\u2010Azam Medical College Bahawalpur Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0004-7389","authenticated-orcid":false,"given":"Nicholas","family":"Aderinto","sequence":"additional","affiliation":[{"name":"Department of Medicine Ladoke Akintola University of Technology Ogbomosho Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6830-4529","authenticated-orcid":false,"given":"Ehsanullah","family":"Alokozay","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Kandahar University Kandahar Afghanistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0490-5954","authenticated-orcid":false,"given":"Caleb","family":"Karani","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences University of Nairobi Nairobi Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassaan","family":"Abid","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Indiana University School of Medicine Muncie Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,14]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.11.010"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.15563"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.124.038644"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.puhe.2023.07.010"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjqcco\/qcae049"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.030438"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40258-013-0070-9"},{"issue":"2","key":"e_1_2_13_9_1","first-page":"89","article-title":"Cardiac Arrhythmias in IHD as Detected by Holter Monitoring","volume":"10","author":"Hulaihil A. 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