{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T07:57:08Z","timestamp":1790582228099,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Long\u2010term oral anticoagulant therapy (OAC) is essential to effective stroke prevention in patients with atrial fibrillation (AF), but adherence to OAC is a concern. Patient self\u2010reported satisfaction with OAC is a major contributor to OAC adherence. We compared the levels of and time trends in patient global satisfaction with rivaroxaban in OAC\u2010na\u00efve and OAC\u2010experienced AF patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An international, prospective, observational study of treatment with generic rivaroxaban included direct oral anticoagulant (DOAC)\u2010eligible AF patients, whether OAC\u2010na\u00efve or previously taking any OAC except rivaroxaban. At enrollment, all participants were prescribed rivaroxaban. Patient self\u2010reported global satisfaction with rivaroxaban was assessed at 3, 6, and 12 months using a modified Treatment Satisfaction Questionnaire for Medication Version 2 (TSQM\u2010II). The lower the TSQM\u2010II value, the higher patient satisfaction level.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 1020 participants (mean age 68.02\u2009\u00b1\u20099.65\u2009y, 43.6% female), 630 (61.8%) were OAC\u2010na\u00efve. The mean patient satisfaction level was consistently higher in OAC\u2010experienced versus OAC\u2010na\u00efve patients across all follow\u2010up visits (1.41\u2009\u00b1\u20090.518 vs. 1.49\u2009\u00b1\u20090.604,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.034, 1.45\u2009\u00b1\u20090.552 vs. 1.56\u2009\u00b1\u20090.585,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004 and 1.40\u2009\u00b1\u20090.511 vs. 1.52\u2009\u00b1\u20090.540,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001 at 3, 6, and 12 months, respectively). OAC\u2010na\u00efve status was consistently significantly associated with the level of patient satisfaction during follow\u2010up, and significant fluctuations in patient satisfaction levels were observed at 6 months among OAC\u2010na\u00efve but not OAC\u2010experienced patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our results suggest that OAC\u2010na\u00efve patients need additional support, reassurance and more intense regular clinical follow\u2010up, particularly in the first 6 months after initiation of DOAC therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/clc.70461","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T09:37:12Z","timestamp":1788341832000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Patient Self\u2010Reported Global Satisfaction With Rivaroxaban in Patients With Atrial Fibrillation: A Comparison Between Oral Anticoagulation\u2010Na\u00efve Versus Oral Anticoagulation\u2010Experienced Patients"],"prefix":"10.1002","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2216-0843","authenticated-orcid":false,"given":"Bogdan G.","family":"Markovic","sequence":"first","affiliation":[{"name":"Medical Faculty University of Belgrade Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9049-1613","authenticated-orcid":false,"given":"Miroslav","family":"Mihajlovic","sequence":"additional","affiliation":[{"name":"Cardiology Clinic, University Clinical Centre of Serbia Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandar","family":"Kocijancic","sequence":"additional","affiliation":[{"name":"Medical Faculty University of Belgrade Belgrade Serbia"},{"name":"Cardiology Clinic, University Clinical Centre of Serbia Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelena","family":"Simic","sequence":"additional","affiliation":[{"name":"Cardiology Clinic, University Clinical Centre of Serbia Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9770-0999","authenticated-orcid":false,"given":"Milan","family":"Marinkovic","sequence":"additional","affiliation":[{"name":"Medical Faculty University of Belgrade Belgrade Serbia"},{"name":"Cardiology Clinic, University Clinical Centre of Serbia Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladan","family":"Kovacevic","sequence":"additional","affiliation":[{"name":"Medical Faculty University of Belgrade Belgrade Serbia"},{"name":"Cardiology Clinic, University Clinical Centre of Serbia Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milica","family":"Ivanisevic","sequence":"additional","affiliation":[{"name":"Cardiology Clinic, University Clinical Centre of Serbia Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikola","family":"Isailovic","sequence":"additional","affiliation":[{"name":"Cardiology Clinic, University Clinical Centre of Serbia Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nebojsa","family":"Mujovic","sequence":"additional","affiliation":[{"name":"Medical Faculty University of Belgrade Belgrade Serbia"},{"name":"Cardiology Clinic, University Clinical Centre of Serbia Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belma","family":"Pojskic","sequence":"additional","affiliation":[{"name":"Department of General Internal medicine Zenica Cantonal Hospital, Faculty of Medicine, University of Zenica Zenica Bosnia and Herzegovina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6285-6902","authenticated-orcid":false,"given":"Tatjana","family":"Potpara","sequence":"additional","affiliation":[{"name":"Medical Faculty University of Belgrade Belgrade Serbia"},{"name":"Cardiology Clinic, University Clinical Centre of Serbia Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the GUARDIAN 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