{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T07:57:10Z","timestamp":1790582230422,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The number of octogenarians and nonagenarians presenting with (NSTEMI) is rising. However, they are underrepresented in studies. Therefore, we aim to clarify patient characteristics and compare all\u2010cause mortality of an initial invasive strategy versus optimal medical treatment in (N)STEMI octo and nonagenarians.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All consecutive patients with (N)STEMI admitted from 2020 until 2023 were included. Patients were divided into invasive and OMT groups. Multi\u2010variation corrected analyses were performed in two age groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>775 consecutive patients &gt;\u200980\u2009years old were analyzed (81\u2009&gt;\u200990\u2009years). A predominance of women, lower hemoglobin levels, eGFR, and lower rates of coronary angiography and PCI were observed in the nonagenarians. Six patients underwent CABG; all were in the 80\u201390\u2010year age group. No differences existed in clinical complication rates between the groups. Invasive treatment demonstrated lower 1\u2009year mortality, predominantly seen in NSTEMI elderly patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In octo and nonagenarian (N)STEMI patients, stratifying to an invasive strategy with PCI\/CABG appears to be feasible and is associated with improved mortality outcomes. This benefit is predominantly observed in patients with NSTEMI. Stratification can be done immediately on common clinical variables and appropriate shared decision\u2010making.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/clc.70463","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T08:14:56Z","timestamp":1788941696000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Outcomes of an Interventional Approach in STEMI and NSTEMI All\u2010Comer Octo and Nonagenarians"],"prefix":"10.1002","volume":"49","author":[{"given":"Charlotte E. P.","family":"Siegers","sequence":"first","affiliation":[{"name":"Department of Cardiology Noordwest Ziekenhuisgroep Alkmaar  the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quinten P.","family":"Hoogervorst","sequence":"additional","affiliation":[{"name":"Department of Cardiology Noordwest Ziekenhuisgroep Alkmaar  the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan van","family":"Ramshorst","sequence":"additional","affiliation":[{"name":"Department of Cardiology Noordwest Ziekenhuisgroep Alkmaar  the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanneke P.M. de","family":"Boer","sequence":"additional","affiliation":[{"name":"Department of Cardiology Noordwest Ziekenhuisgroep Alkmaar  the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3263-4054","authenticated-orcid":false,"given":"Maurits","family":"Dirksen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Noordwest Ziekenhuisgroep Alkmaar  the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5587-9097","authenticated-orcid":false,"given":"Victor A. W. M.","family":"Umans","sequence":"additional","affiliation":[{"name":"Department of Cardiology Noordwest Ziekenhuisgroep Alkmaar  the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2004.06.003"},{"issue":"1","key":"e_1_2_8_3_1","first-page":"17","article-title":"E.A. Is the Contemporary Care of the Older Persons With Acute Coronary Syndrome Evidence\u2010Based?","volume":"2","author":"Mills G. B.","year":"2021","journal-title":"European Heart Journal Open [Internet]"},{"key":"e_1_2_8_4_1","unstructured":"2023ESC Guidelines for the Management of Acute Coronary Syndromes [Internet]https:\/\/www.escardio.org\/Guidelines\/Clinical-Practice-Guidelines\/Acute-Coronary-Syndromes-ACS-Guidelines."},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq375"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(15)01166-6"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa2407791"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.0809"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12471-023-01812-0"},{"key":"e_1_2_8_10_1","first-page":"2006","article-title":"Beyond Longevity","volume":"73","author":"Jamil Y.","year":"2025","journal-title":"Prioritizing Individualized Care in Older"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.19525"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2019.09.008"},{"key":"e_1_2_8_13_1","unstructured":"Acuut coronair syndroom [Internet]. NHG\u2010Richtlijnen.https:\/\/richtlijnen.nhg.org\/standaarden\/acuut-coronair-syndroom#volledige-tekst(accessed Dec 20 2025)."},{"key":"e_1_2_8_14_1","unstructured":"Life expectancy: recent trends in older ages.www.gov.uk\/government\/publications\/life-expectacy(accessed Dec 20 2025)."},{"key":"e_1_2_8_15_1","unstructured":"Levensverwachting en sterfte | Trendscenario VTV\u20102024 | Volksgezondheid Toekomst Verkenning 2024 accessed Dec2025."},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/2048872619877287"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.01.369"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.4244\/eij-d-18-00099"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(20)30930-2"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(02)01878-8"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00029330-200607020-00002"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10433-021-00620-y"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjacc\/zuad151"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-021-01933-7"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12471-022-01672-0"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.70463","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/clc.70463","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.70463","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T07:30:23Z","timestamp":1790580623000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.70463"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":24,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/clc.70463"],"URL":"https:\/\/doi.org\/10.1002\/clc.70463","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2026-02-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70463"}}