{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T07:57:10Z","timestamp":1790582230653,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T00:00:00Z","timestamp":1788652800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"ABSTRACT<\/jats:title>\n \n Introduction<\/jats:title>\n Heart failure with reduced ejection fraction (HFrEF), defined by a left ventricular ejection fraction \u2264\u200940%, remains a major global health challenge, associated with substantial morbidity, mortality, and impaired quality of life (QoL), particularly in patients with higher NYHA class. Sodium\u2013glucose cotransporter\u20102 (SGLT2) inhibitors have emerged as a cornerstone therapy for HFrEF, significantly reducing hospitalizations and mortality regardless of glycemic status, sex, race, or comorbidities.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n EVOLUTION\u2010HF was an observational, multi\u2010center, longitudinal cohort study involving 257 consecutive patients diagnosed with HFrEF who initiated dapagliflozin in a routine clinical setting in Greece. The primary objectives were to characterize baseline demographic and clinical features of patients newly initiated on dapagliflozin for HFrEF and to evaluate dapagliflozin treatment patterns, including discontinuation timing, reasons for discontinuation, and concomitant heart failure and glucose\u2010lowering therapies over time. The secondary objectives are to describe patient\u2010reported outcomes using the KCCQ\u201023 and to assess adherence to dapagliflozin among patients with HFrEF.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n A total of 257 patients were enrolled and the follow\u2010up period lasted for 12 months. Significant improvements among all KCCQ\u201023 scores were observed from baseline to 12\u2010months post dapagliflozin initiation, revealing that the initiation and optimization of guideline\u2010directed medical therapy in routine clinical practice provides improvement to quality of life over time.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Dapagliflozin was safe and well\u2010tolerated throughout the observation period. Although benefits are observed in most patients, individuals aged >\u200965 years, with prior myocardial infarction, or recent hospitalizations show a diminished response, underscoring the need for tailored management and closer follow\u2010up in these higher\u2010risk groups.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/clc.70466","type":"journal-article","created":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T12:34:55Z","timestamp":1788698095000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prospective Evaluation of Quality\u2010of\u2010Life Improvement After Dapagliflozin Initiation in a Greek Population With HFrEF: The EVOLUTION\u2010HF 12\u2010Month Results"],"prefix":"10.1002","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3364-7121","authenticated-orcid":false,"given":"Victoria","family":"Potoupni","sequence":"first","affiliation":[{"name":"Third Cardiology Department, Hippokrateion General Hospital, School of Medicine Aristotle University of Thessaloniki Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5008-114X","authenticated-orcid":false,"given":"Aristi","family":"Boulmpou","sequence":"additional","affiliation":[{"name":"Third Cardiology Department, Hippokrateion General Hospital, School of Medicine Aristotle University of Thessaloniki Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1851-5980","authenticated-orcid":false,"given":"Spyridon","family":"Maragkoudakis","sequence":"additional","affiliation":[{"name":"Department of Cardiology Chania General Hospital \u2018Agios Georgios\u2019 Chania Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5740-9670","authenticated-orcid":false,"given":"Alexandros","family":"Briasoulis","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics, Alexandra Hospital, Faculty of Medicine National and Kapodistrian University of Athens Psachna Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1340-2282","authenticated-orcid":false,"given":"Emmanouil","family":"Foukarakis","sequence":"additional","affiliation":[{"name":"Department of Cardiology Venizeleion General Hospital Heraklion Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexia","family":"Stavrati","sequence":"additional","affiliation":[{"name":"Department of Cardiology General Hospital G. Papanikolaou Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Papadopoulos","sequence":"additional","affiliation":[{"name":"2nd Cardiology Department \u201cKorgialenio\u2010Benakio\u201d Red Cross Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9900-9659","authenticated-orcid":false,"given":"Katerina K.","family":"Naka","sequence":"additional","affiliation":[{"name":"2nd Department of Cardiology, Faculty of Medicine School of Health Sciences, University of Ioannina, and University Hospital of Ioannina Ioannina Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Kotsia","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ioannina State General Hospital \u201cG. 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