{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T14:49:52Z","timestamp":1792162192302,"version":"4.4.0"},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Respiratory syncytial virus (RSV) is increasingly recognized as a trigger for adverse outcomes in older adults with heart failure (HF). Following FDA approval of RSV vaccines for adults \u2265\u200960 years in 2023, real\u2010world evidence in HF populations remains limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a multicenter retrospective cohort study using the TriNetX US Collaborative Network. Adults \u2265\u200960 years with HF were identified and stratified by RSV vaccination status from May 1, 2023, to January 01, 2026. Propensity score matching (1:1) was performed. The primary outcome was all\u2010cause mortality. Secondary outcomes included respiratory failure, healthcare utilization, and cardiovascular events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After PSM, 777 vaccinated and 777 unvaccinated HF patients were analyzed. All\u2010cause mortality (HR 0.51, 95% CI, 0.33\u22120.79) and ICU admissions were significantly lower in vaccinated patients (2.7% vs. 5.8%, HR 0.46, 95% CI 0.25\u20130.86), while healthcare utilization was significantly higher in the vaccinated cohort (HR 1.85, 95% CI 1.65\u20132.08). No significant differences were observed in respiratory failure (7.3% vs. 9.4%, HR 0.87, 95% CI 0.61\u20131.23), inpatient or emergency visits (29.9% vs. 35.1%, HR 0.97, 95% CI 0.81\u20131.16), HF exacerbations, myocardial infarction, or stroke. Age\u2010stratified subgroup analyses (60\u201375 and 75\u201390 years) showed consistent findings, with no significant cardiovascular differences and significantly higher healthcare utilization in vaccinated patients across both age groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In older adults with HF, RSV vaccination was associated with lower mortality and fewer ICU admissions, without a corresponding reduction in overall inpatient\/emergency use or acute\u2010care utilization. These findings are hypothesis\u2010generating and may reflect prevention of severe respiratory illness.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/clc.70488","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:50:00Z","timestamp":1791291000000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of RSV Vaccination With Clinical Outcomes in Older Adults With Heart Failure: A Propensity\u2010Matched Analysis"],"prefix":"10.1002","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2003-922X","authenticated-orcid":false,"given":"Allahdad","family":"Khan","sequence":"first","affiliation":[{"name":"Department of Medicine Nishtar Medical University Multan Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9907-4469","authenticated-orcid":false,"given":"Muhammad Raffey","family":"Shabbir","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Marshfield Clinic, Sanford Health Marshfield Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2651-9827","authenticated-orcid":false,"given":"Jamil","family":"Nasrallah","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medical Sciences Lebanese University Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3600-7578","authenticated-orcid":false,"given":"Mahrukh","family":"Imtiaz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Marshfield Clinic, Sanford Health Marshfield Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0457-5851","authenticated-orcid":false,"given":"Harshith","family":"Thyagaturu","sequence":"additional","affiliation":[{"name":"Department of Cardiology West Virginia University Morgantown West Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marat","family":"Fudim","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology Duke University School of Medicine Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3222-1719","authenticated-orcid":false,"given":"Robert J.","family":"Mentz","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology Duke University School of Medicine Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3192-8093","authenticated-orcid":false,"given":"Gregg C.","family":"Fonarow","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology Geffen School of Medicine at UCLA Los Angeles California 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