{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T13:32:25Z","timestamp":1793194345539,"version":"4.5.0"},"reference-count":14,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Left\u2010ventricular end\u2010systolic dimension (LVESD) and end\u2010diastolic dimension (LVEDD) are associated with adverse outcomes in heart failure (HF). The prognostic significance of a change in LVESD or LVEDD is uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study included patients experiencing \u2265\u20091 HF hospitalization or emergency department (ED) visit between April 2008 and March 2016 and underwent \u2265\u20092 echocardiograms, separated by \u2265\u20096 months. The primary outcome was the composite all\u2010cause mortality, HF hospitalization, and ED visits for HF. We performed cut\u2010point analysis to determine the threshold increase in LVESD or LVEDD associated with all\u2010cause mortality. We evaluated characteristics associated with an increase in LVESD and LVEDD above threshold using multivariable logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 8790 patients, 56.1% were male, with a mean (SD) age of 70.9 (14.5). The thresholds for change in LVESD and LVEDD associated with all\u2010cause mortality were \u22123.13% and 1.33%, respectively. Patients with ischemic cardiomyopathy and lower LVEF were at increased risk of a change in LV size above the threshold. There was a significant association between an increase in LVESD or LVEDD above threshold and the composite outcome (HR 1.13; 95% CI 1.06, 1.20; HR 1.07; 95% CI 1.01, 1.13, respectively). An increase in LVESD or LVEDD above threshold was associated with increased risk of HF hospitalization (HR 1.27; 95% CI 1.15, 1.39; HR 1.24; 95% CI 1.12, 1.36) and an increased risk of ED visits for HF (HR 1.25; 95% CI 1.15, 1.37; HR 1.16; 95% CI 1.06, 1.26).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Small adverse changes in linear dimensions of LVESD and LVEDD are clinically significant in patients with HF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/clc.70490","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:23:47Z","timestamp":1791379427000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic Significance and Factors Associated With Worsening LV Dilatation in Heart Failure"],"prefix":"10.1002","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9383-9312","authenticated-orcid":false,"given":"Tauben","family":"Averbuch","sequence":"first","affiliation":[{"name":"Department of Cardiac Sciences, Division of Cardiology Libin Cardiovascular Institute, Cumming School of Medicine Calgary Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4676-2433","authenticated-orcid":false,"given":"Robert J. H.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Cardiac Sciences, Division of Cardiology Libin Cardiovascular Institute, Cumming School of Medicine Calgary Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2724-4086","authenticated-orcid":false,"given":"Justin","family":"Ezekowitz","sequence":"additional","affiliation":[{"name":"Department of Medicine, Canadian VIGOUR Center University of Alberta Edmonton Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0535-9771","authenticated-orcid":false,"given":"Jonathan G.","family":"Howlett","sequence":"additional","affiliation":[{"name":"Department of Cardiac Sciences, Division of Cardiology Libin Cardiovascular Institute, Cumming School of Medicine Calgary Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7435-3341","authenticated-orcid":false,"given":"Finlay A.","family":"McAlister","sequence":"additional","affiliation":[{"name":"Department of Medicine, Canadian VIGOUR Center University of Alberta Edmonton Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0654-4469","authenticated-orcid":false,"given":"Erik","family":"Youngson","sequence":"additional","affiliation":[{"name":"Data and Research Services, Alberta Support Unit and Provincial Research Data Services Alberta Health Services Calgary Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6546-6587","authenticated-orcid":false,"given":"Nowell M.","family":"Fine","sequence":"additional","affiliation":[{"name":"Department of Cardiac Sciences, Division of Cardiology Libin Cardiovascular Institute, Cumming School of Medicine Calgary Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcdd9120421"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.114.001566"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.114.001193"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.846361"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.967039"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2011.07.008"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.017822"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.2459\/JCM.0000000000001480"},{"issue":"4","key":"e_1_2_11_10_1","first-page":"305","article-title":"E\/A Ratio Before Cardiac Resynchronization Therapy Predicts Left Ventricle Reverse 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