{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T09:43:40Z","timestamp":1792748620711,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The clinical relevance of chronic total occlusion (CTO) revascularization in patients with non\u2013ST\u2010segment elevation myocardial infarction (NSTEMI) and multivessel disease (MVD) remains uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this multicenter retrospective cohort study, 632 patients with NSTEMI, MVD, and CTO were included. Patients were categorized into a complete revascularization group involving successful CTO recanalization (CR\u2010CTO,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009119) and an incomplete revascularization group without successful CTO recanalization (ICR\u2010CTO,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009513). The primary endpoints were major adverse cardiovascular and cerebrovascular events (MACCE) and major adverse cardiovascular events (MACE).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During a mean follow\u2010up of 528\u2009\u00b1\u2009201 days, the incidences of MACCE (11.8% vs. 28.5%) and MACE (7.6% vs. 24.2%) were significantly lower in the CR\u2010CTO group than in the ICR\u2010CTO group (both\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). In multivariable Cox regression analyses, CR\u2010CTO was independently associated with lower risks of MACCE (hazard ratio [HR], 0.35; 95% confidence interval [CI], 0.20\u20130.61) and MACE (HR, 0.26; 95% CI, 0.13\u20130.51). Among patients without successful CTO recanalization, additional revascularization of non\u2010CTO lesions was not associated with improved outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In patients with NSTEMI, MVD, and CTO, complete revascularization involving successful CTO recanalization was associated with improved mid\u2010term clinical outcomes. In contrast, additional revascularization of non\u2010CTO lesions alone was not associated with a prognostic benefit when CTO lesions remained unrevascularized. These findings suggest that CTO revascularization status may warrant specific consideration when revascularization strategies are evaluated in this patient population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/clc.70491","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T09:28:41Z","timestamp":1792661321000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mid\u2010Term Clinical Outcomes According to CTO Revascularization Status in Patients With NSTEMI and Multivessel Disease"],"prefix":"10.1002","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2250-3508","authenticated-orcid":false,"given":"Wei","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Cardiology, Xuzhou Central Hospital Xuzhou Clinical College of Xuzhou Medical University Xuzhou Jiangsu China"},{"name":"Department of Cardiology, Xuzhou Central Hospital Southeast University Xuzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3861-2426","authenticated-orcid":false,"given":"Yuling","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ultrasonography, Xuzhou Central Hospital Southeast University Xuzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Cardiology Affiliated Hospital of Chengde Medical University Chengde Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jixian","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Cardiology Cangzhou People's Hospital Cangzhou Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Information Center Yuncheng Central Hospital Yuncheng Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6405-0862","authenticated-orcid":false,"given":"Chongyou","family":"Rao","sequence":"additional","affiliation":[{"name":"Medical Innovation Research Division Chinese PLA General Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3523-0573","authenticated-orcid":false,"given":"Bing","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Xuzhou Central Hospital Xuzhou Clinical College of Xuzhou Medical University Xuzhou Jiangsu China"},{"name":"Department of Cardiology, Xuzhou Central Hospital Southeast University Xuzhou Jiangsu 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