{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T09:43:32Z","timestamp":1792748612448,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62172288"],"award-info":[{"award-number":["62172288"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acute coronary occlusion (ACO) occurs in approximately one\u2010quarter of patients with non\u2010ST\u2010segment elevation myocardial infarction (NSTEMI) and is associated with adverse outcomes. This study aimed to develop and validate a prediction model for ACO.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Consecutive patients admitted with NSTEMI between January 2016 and June 2023 who underwent coronary angiography were enrolled. Demographic, electrocardiographic, laboratory, and echocardiographic data were collected. Patients admitted during 2016\u22122020 were assigned to the training cohort (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009670), and those admitted during 2021\u22122023 were assigned to the validation cohort (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009334). Predictors were selected using least absolute shrinkage and selection operator regression, and a nomogram was constructed based on multivariable logistic regression. Model performance was assessed by receiver operating characteristic (ROC) curves, calibration curves, and decision curve analysis (DCA).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 1,004 patients, 262 (26.1%) had ACO. Seven predictors, including smoking history, ST\u2010segment depression\u2009\u2265\u20091\u2009mm, regional wall motion abnormality, left ventricular ejection fraction, admission cardiac troponin I, interleukin\u20106, and high\u2010sensitivity C\u2010reactive protein, were incorporated into the model. The area under the ROC curve was 0.731 (95% CI, 0.688\u22120.773) in the training cohort and 0.715 (95% CI, 0.654\u22120.776) in the validation cohort. Calibration curves showed good agreement between predicted and observed probabilities, and DCA demonstrated favorable clinical utility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study developed and validated a multidimensional prediction model for ACO in patients with NSTEMI. The model showed acceptable performance and may aid early identification before coronary angiography, although reliance on IL\u20106, which is not routinely available in all centers, may limit its generalizability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/clc.70492","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T09:52:47Z","timestamp":1792662767000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Development and Validation of a Prediction Model for Acute Coronary Occlusion in Patients With Non\u2010ST\u2010Segment Elevation Myocardial Infarction"],"prefix":"10.1002","volume":"49","author":[{"given":"Qicheng","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Emergency, Xuanwu Hospital, Capital Medical University National Clinical Research Center for Geriatric Diseases Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1636-5525","authenticated-orcid":false,"given":"Shuai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Emergency, Xuanwu Hospital, Capital Medical University National Clinical Research Center for Geriatric Diseases Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9569-2788","authenticated-orcid":false,"given":"Yuanyuan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Emergency, Xuanwu Hospital, Capital Medical University National Clinical Research Center for Geriatric Diseases Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2315-3504","authenticated-orcid":false,"given":"Yanlong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Emergency, Xuanwu Hospital, Capital Medical University National Clinical Research Center for Geriatric Diseases Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Emergency, Xuanwu Hospital, Capital Medical University National Clinical Research Center for Geriatric Diseases Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanling","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Xuanwu Hospital, Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenxing","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Xuanwu Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8140-8707","authenticated-orcid":false,"given":"Fangyan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Emergency, Xuanwu Hospital, Capital Medical University National Clinical Research Center for Geriatric Diseases Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9791-7290","authenticated-orcid":false,"given":"Zhi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Emergency, Xuanwu Hospital, Capital Medical University National Clinical Research Center for Geriatric Diseases Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,22]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)00367-2"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0903515"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.122.059678"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)00476-8"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2004.06.003"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.897249"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.030798"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-020-01612-1"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0908610"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2019-315655"},{"issue":"13","key":"e_1_2_12_12_1","first-page":"e771","article-title":"2025 ACC\/AHA\/ACEP\/NAEMSP\/SCAI Guideline for the Management of Patients With Acute Coronary Syndromes: A Report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"151","author":"Rao S. 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