{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T09:44:26Z","timestamp":1792748666131,"version":"4.5.0"},"reference-count":32,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:00:00Z","timestamp":1792108800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n Heart failure with preserved ejection fraction (HFpEF) is difficult to diagnose in older adults. The H\n 2<\/jats:sub>\n FPEF score estimates the likelihood of HFpEF and has been associated with adverse prognosis, but its performance has not been evaluated in geriatric inpatients with a high comorbidity burden.\n <\/jats:p>\n <\/jats:sec>\n \n Hypothesis<\/jats:title>\n \n We hypothesized that the H\n 2<\/jats:sub>\n FPEF score predicts adverse outcomes in geriatric inpatients independently of comorbidity burden.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This prospective cohort included consecutive patients admitted to a geriatric rehabilitation unit. All patients underwent functional and echocardiographic assessment at admission. The ability of the H\n 2<\/jats:sub>\n FPEF score, the Charlson comorbidity index (CCI), and their combination to predict 1\u2010year all\u2010cause mortality (ACM) or cardiovascular rehospitalization (CR) was evaluated.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Among 302 patients (median age 83 years, 40% men), 24% had a H\n 2<\/jats:sub>\n FPEF score\u2009\u2265\u20096 indicating high HFpEF probability and 42% had a CCI\u2009>\u20093 indicating high comorbidity burden. The H\n 2<\/jats:sub>\n FPEF score correlated with CCI (\n \u03b2<\/jats:italic>\n \u2009=\u20090.27,\n p<\/jats:italic>\n \u2009<\u20090.01) and functional disability (lower Instrumental Activities of Daily Living score;\n \u03b2<\/jats:italic>\n \u2009=\u2009\u22120.17,\n p<\/jats:italic>\n \u2009=\u20090.003), but not with cognitive impairment. Both a high H\n 2<\/jats:sub>\n FPEF score and high CCI were associated with a higher risk of the combined outcome of 1\u2010year ACM or CR (adjusted HR 2.89 [95% CI 1.63\u20135.10],\n p<\/jats:italic>\n \u2009<\u20090.001 and adjusted HR 2.66 [95% CI 1.67\u20134.21],\n p<\/jats:italic>\n \u2009<\u20090.001, respectively), with no interaction between them (\n p<\/jats:italic>\n \u2009=\u20090.63). Patients with both high\u2010risk scores had the highest risk (adjusted HR 4.66 [95% CI 2.54\u20138.57],\n p<\/jats:italic>\n \u2009<\u20090.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n In geriatric inpatients, a high H\n 2<\/jats:sub>\n FPEF score is common and independently identifies patients at increased risk of adverse cardiovascular outcomes at 1 year.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/clc.70496","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T14:35:51Z","timestamp":1792161351000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["H\n 2<\/sub>\n FPEF Score and Charlson Comorbidity Index as Independent Predictors of Cardiovascular Outcomes in Elderly Patients Undergoing Geriatric Rehabilitation"],"prefix":"10.1002","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6109-4317","authenticated-orcid":false,"given":"Nicolas","family":"Dayer","sequence":"first","affiliation":[{"name":"Service of Cardiology University Hospital of Lausanne (CHUV) and University of Lausanne (Unil) Lausanne Switzerland"},{"name":"Service of Cardiology Centre Hospitalier du Valais Romand (CHVR) Sion Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Auberson","sequence":"additional","affiliation":[{"name":"Service of Cardiology University Hospital of Lausanne (CHUV) and University of Lausanne (Unil) Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9074-6505","authenticated-orcid":false,"given":"Henri","family":"Lu","sequence":"additional","affiliation":[{"name":"Service of Cardiology University Hospital of Lausanne (CHUV) and University of Lausanne (Unil) Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsa","family":"Costa","sequence":"additional","affiliation":[{"name":"Service of Cardiology University Hospital of Lausanne (CHUV) and University of Lausanne (Unil) Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Krief","sequence":"additional","affiliation":[{"name":"Service of Geriatrics University Hospital of Lausanne (CHUV) and University of Lausanne (Unil) Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Service of Geriatrics University Hospital of Lausanne (CHUV) and University of Lausanne (Unil) Lausanne Switzerland"},{"name":"Service of Geriatrics Riviera\u2010Chablais Hospital (HRC) Rennaz Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristof","family":"Major","sequence":"additional","affiliation":[{"name":"Service of Geriatrics University Hospital of Lausanne (CHUV) and University of Lausanne (Unil) Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanda","family":"Bosshard","sequence":"additional","affiliation":[{"name":"Service of Geriatrics University Hospital of Lausanne (CHUV) and University of Lausanne (Unil) Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5738-1903","authenticated-orcid":false,"given":"Roger","family":"Hullin","sequence":"additional","affiliation":[{"name":"Service of Cardiology University Hospital of Lausanne (CHUV) and University of Lausanne (Unil) Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3083-7333","authenticated-orcid":false,"given":"Pierre","family":"Monney","sequence":"additional","affiliation":[{"name":"Service of Cardiology University Hospital of Lausanne (CHUV) and University of Lausanne (Unil) Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,16]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.15420\/cfr.2023.03"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab368"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp2305181"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.023361"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad195"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz641"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-03140-1"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.034646"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2022.1916"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.13187"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2025.102526"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2026.06.018"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.162.15.1689"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jeab253"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2018.06.004"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jev014"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jew335"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s44156-024-00048-x"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jew082"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jeab154"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780040112"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2020.03.013"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1542"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.111.966366"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euad095"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2019.10.005"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2019.10.005"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1926"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.17752"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.3416"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc21-2434"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.14077"}],"container-title":["Clinical 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