{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T09:43:23Z","timestamp":1792748603118,"version":"4.5.0"},"reference-count":38,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Limited data are available on the association between early longitudinal changes in platelet count and mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to compare the early longitudinal changes in platelet count between survivors and non\u2010survivors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a retrospective multi\u2010center cohort study using data from the eICU Collaborative Research Database. A total of 6,769 patients diagnosed with AMI were included in the study. The analysis employed a Generalized Additive Model (GAM) and a Generalized Additive Mixed Model (GAMM) to compare longitudinal changes in platelet count between survivors and non\u2010survivors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The ICU 28\u2010day and ICU 7\u2010day all\u2010cause mortality were 6.1% and 4.6%, respectively. During the first 5 days of ICU admission, GAM showed that non\u2010survivors exhibited a significantly greater decline in platelet count than survivors. Specifically, the GAMM results showed that the difference in platelet count between ICU 28\u2010day non\u2010survivors and ICU 28\u2010day survivors increased by an average of 15.4\u2009\u00d7\u200910\n                      <jats:sup>9<\/jats:sup>\n                      \/L daily (95% Confidence Interval [CI], 14.1 to 16.7;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Similarly, the difference in platelet count between ICU 7\u2010day non\u2010survivors and ICU 7\u2010day survivors increased by an average of 18.0\u2009\u00d7\u200910\n                      <jats:sup>9<\/jats:sup>\n                      \/L daily (95% CI, 16.1\u221219.8;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>An early longitudinal decline in platelet count was associated with a poor prognosis in patients with AMI. However, this study is observational, and causality cannot be inferred.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/clc.70504","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T09:48:12Z","timestamp":1792662492000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An Early Longitudinal Decrease in Platelet Count Is Associated With Poor Prognosis in Acute Myocardial Infarction Patients: A Multicenter Retrospective Study"],"prefix":"10.1002","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3252-5090","authenticated-orcid":false,"given":"Tianlai","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Intensive Care Unit Quanzhou First Hospital Affiliated to Fujian Medical University Fujian 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Hospital Affiliated to Fujian Medical University Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xizhe","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Unit Quanzhou First Hospital Affiliated to Fujian Medical University Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2538-6256","authenticated-orcid":false,"given":"Youli","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Unit Quanzhou First Hospital Affiliated to Fujian Medical University Fujian 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