{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T12:09:03Z","timestamp":1782821343493,"version":"3.54.5"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,3,15]],"date-time":"2021-03-15T00:00:00Z","timestamp":1615766400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp; Translational All"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic rhinosinusitis (CRS) has a high prevalence of anxiety and depression. It is currently uncertain if treatment in patients with CRS with or without nasal polyps (CRSwNP and CRSsNP) has any impact on improving mental health outcomes. The aims here were to document anxiety and depression in patients with severe CRS and asthma already treated with appropriate medical therapy. We then evaluated whether further maximal treatment with omalizumab improved anxiety and\/or depression alongside improvements in CRS and coassociated asthma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Hospital Anxiety and Depression Scale (HADS) scores along with measures of CRS and asthma severity were recorded according to CRSwNP and CRSsNP status in <jats:italic>n<\/jats:italic>\u00a0=\u00a095 patients with severe CRS and asthma. Of this group, a further <jats:italic>n<\/jats:italic>\u00a0=\u00a023 had omalizumab for associated allergic asthma. Follow\u2010up measures were collected 16\u00a0weeks after omalizumab treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>HADS anxiety and depression prevalence in CRS were 49.47 % and 38.95%, respectively. Within the CRSwNP and CRSsNP group 53.06% and 45.66% had raised HADS\u2010anxiety scores. Abnormal HADS\u2010depression scores were present in 40.82% and 36.95% of the CRSwNP and CRSsNP groups, respectively. Correlations for sinonasal outcome test\u201022 (SNOT\u201022) versus HADS total was <jats:italic>r<\/jats:italic>\u00a0=\u00a00.59 <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001, HADS\u2010anxiety <jats:italic>r<\/jats:italic>\u00a0=\u00a00.56 <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001 and HADS\u2010depression <jats:italic>r<\/jats:italic>\u00a0=\u00a00.49 <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001. Omalizumab improved anxiety in CRS (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001) regardless of nasal polyp status (CRSwNP <jats:italic>p<\/jats:italic>\u00a0=\u00a00.0042 and CRSsNP <jats:italic>p<\/jats:italic>\u00a0=\u00a00.0078). Depression scores did not improve in either group. SNOT\u201022 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.0006), asthma control questionnaire\u20107 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.0019) and mini\u2010asthma quality of life questionnaire including emotional function (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.0003 and <jats:italic>p<\/jats:italic>\u00a0=\u00a00.0009, respectively) all improved in both subgroups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In CRS and asthma, anxiety scores but not depression improved after omalizumab treatment. Anxiety may be closely related to airway disease severity, but depression may be independent of airway disease itself. If so, a separate mental health care pathway is needed for CRS patients with depression.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clt2.12002","type":"journal-article","created":{"date-parts":[[2021,3,15]],"date-time":"2021-03-15T17:45:12Z","timestamp":1615830312000},"source":"Crossref","is-referenced-by-count":12,"title":["Chronic rhinosinusitis with and without nasal polyps and asthma: Omalizumab improves residual anxiety but not depression"],"prefix":"10.1002","volume":"11","author":[{"given":"Florian","family":"Vogt","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine University College London Hospital NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jagdeep","family":"Sahota","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine University College London Hospital NHS Foundation Trust  London UK"},{"name":"Rhinology UCL Ear Institute University College London  London 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