{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:35:58Z","timestamp":1790393758960,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T00:00:00Z","timestamp":1617148800000},"content-version":"vor","delay-in-days":30,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670913"],"award-info":[{"award-number":["81670913"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970859"],"award-info":[{"award-number":["81970859"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp; Translational All"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Tissue remodeling is a crucial characteristic of chronic rhinosinusitis (CRS). Imbalance between matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) is crucial for the pathologic tissue remodeling in CRS. Elevation of interleukin (IL)\u201019 or MMP\u20109 levels in patients with CRS had been proven in previous studies. Here, we aimed to investigate the role of IL\u201019 in mediating MMP\u20109 expression in CRS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Nasal tissue samples were collected from 45 individuals having chronic rhinosinusitis with nasal polyps (CRSwNP), 24 CRS without nasal polyps (CRSsNP), and 17 controls. Expression of IL\u201019, its receptors (IL\u201020R1\/IL\u201020R2), and MMP\u20109 were investigated using RT\u2010qPCR and Immunofluorescence (IF). Human nasal epithelial cells (HNECs) were stimulated by IL\u201019; ERK phosphorylation,\u00a0nuclear factor\u2010\u03baB (NF\u2010\u03baB) pathway activation, and MMP\u20109 level were detected by RT\u2010qPCR, enzyme\u2010linked immunosorbent assay, western blot, and IF. We also explored the effect of type1\/2\/3 cytokines on IL\u201019 production by RT\u2010qPCR, and western blot.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Expression levels of IL\u201019, its receptors (IL\u201020R1\/IL\u201020R2), and MMP\u20109 were increased in nasal tissues from individuals with CRSwNP compared to those with CRSsNP as well as the controls. IL\u201019 significantly elevated the production of MMP\u20109 in HNECs. Furthermore, IL\u201019 could activate the ERK and NF\u2010\u03baB pathways, accompanied by increased MMP\u20109 production in HNECs. Conversely, both ERK and NF\u2010\u03baB inhibitors significantly attenuated the role of IL\u201019 in MMP\u20109 production. siRNA knockdown of IL\u201020R1 suppressed ERK and NF\u2010\u03baB pathway activation, thereby decreasing MMP\u20109 expression. IL\u201013 and IL\u201017A were found to stimulate IL\u201019 production in HNECs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>IL\u201019, promoted by IL\u201013 and IL\u201017A, contributes to the upregulation of secretion of the tissue remodeling factor MMP\u20109 in patients with CRS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clt2.12003","type":"journal-article","created":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T11:53:42Z","timestamp":1617191622000},"source":"Crossref","is-referenced-by-count":17,"title":["IL\u201019 induced by IL\u201013\/IL\u201017A in the nasal epithelium of patients with chronic rhinosinusitis upregulates MMP\u20109 expression via ERK\/NF\u2010\u03baB signaling pathway"],"prefix":"10.1002","volume":"11","author":[{"given":"Xia","family":"Li","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology The Third Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou 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