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Of these, 25,257 were additionally tested for sIgE to inhalation allergens (Phadiatop).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of sIgE sensitization, AR, AC, and asthma was 30%, 19%, 15%, and 9%, respectively. The youngest birth cohorts had the highest prevalence of sIgE sensitization and symptoms of asthma, AR, and AC, and for asthma, they apparently experienced symptoms at an earlier age. The sIgE sensitization was positively associated with male sex. The sIgE seroprevalence was higher in participants with both AR and AC (ARC) than in participants with either AR or AC. Allergic predisposition and sIgE sensitization increased the risk of the diseases, while farm upbringing was associated with reduced prevalence of ARC, however, only in sIgE sensitized participants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Birth year, childhood residence, sIgE sensitization, and allergic predisposition were associated with asthma, AR, and AC prevalence. Individuals with self\u2010reported ARC represent a primarily sIgE\u2010positive phenotype, while those with either AR or AC represent more diverse phenotypes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clt2.12013","type":"journal-article","created":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T15:21:31Z","timestamp":1617117691000},"source":"Crossref","is-referenced-by-count":11,"title":["Combinations of self\u2010reported rhinitis, conjunctivitis, and asthma predicts IgE sensitization in more than 25,000 Danes"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7806-1143","authenticated-orcid":false,"given":"Susan","family":"Mikkelsen","sequence":"first","affiliation":[{"name":"Department of Clinical Immunology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khoa Manh","family":"Dinh","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Aarhus University 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