{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T11:44:33Z","timestamp":1771501473534,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T00:00:00Z","timestamp":1627344000000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp; Translational All"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>When initiating the Danish vaccination program against COVID\u201019, the incidence of anaphylaxis was estimated to be 10 times higher compared to other virus\u2010based vaccines. In this study, we present data on patients referred with suspected allergic reactions to COVID\u201019 vaccines. The main purpose of the study is to investigate the incidence and severity of the allergic reactions, and to evaluate the safety of revaccination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All patients in the region of Southern Denmark with case histories of allergic reactions to COVID\u201019 vaccines in a defined period are included in this study. Diagnostic work up consisted of a detailed case history, evaluation of Brighton level of diagnostic certainty and World Allergy Organization grade of anaphylaxis and skin prick testing\u2010 and basophil histamine release testing with COVID\u201019 vaccines and relevant drug excipients. Patients were revaccinated at the Allergy Center when possible.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010one patients are included in this study. In 199,377 doses administered, nine patients fulfilled the criteria of anaphylaxis when using the Brighton Criteria (incidence being 45 per million). Of 55 patients with reactions to the first dose, 52 patients were revaccinated without adverse reactions. We found no proven cases of immediate anaphylaxis due to COVID\u201019 vaccines. By skin prick test, we diagnosed three patients with drug excipient allergy and further a patient with mastocytosis was found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Anaphylactic reactions to COVID\u201019 vaccines are rare and the incidence is similar to what is seen with other virus\u2010based vaccines. Revaccination is safe in the majority of patients; however, allergological evaluation is important since some prove to have drug excipient allergy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clt2.12044","type":"journal-article","created":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T16:29:57Z","timestamp":1627403397000},"source":"Crossref","is-referenced-by-count":33,"title":["Patients with suspected allergic reactions to COVID\u201019 vaccines can be safely revaccinated after diagnostic work\u2010up"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2761-8153","authenticated-orcid":false,"given":"Trine Holm","family":"Rasmussen","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy Center Odense Research Centre for Anaphylaxis (ORCA) Odense University Hospital  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8710-0829","authenticated-orcid":false,"given":"Charlotte Gotthard","family":"Mortz","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Center Odense Research Centre for Anaphylaxis (ORCA) Odense University Hospital  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torbjorn Kabel","family":"Georgsen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Center Odense Research Centre for Anaphylaxis (ORCA) Odense University Hospital  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helene Marlies","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Center Odense Research Centre for Anaphylaxis (ORCA) Odense University Hospital  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8043-0718","authenticated-orcid":false,"given":"Henrik Fomsgaard","family":"Kjaer","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Center Odense Research Centre for Anaphylaxis (ORCA) Odense University Hospital  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8940-038X","authenticated-orcid":false,"given":"Carsten","family":"Bindslev\u2010Jensen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Center Odense Research Centre for Anaphylaxis (ORCA) Odense University Hospital  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,7,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.07.048"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7002e1"},{"key":"e_1_2_8_4_1","volume-title":"Guidelines for Management of Vaccination against COVID\u201019","author":"Danish Health Authorities (SST)","year":"2021"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2021.03.041"},{"key":"e_1_2_8_6_1","unstructured":"Statens Serum Institut (SSI). 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