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Aspirin desensitization followed by daily high\u2010dose aspirin therapy is a safe and effective treatment option for the majority of patients with AERD. However, there is still some percentage of the population who do not derive benefits from daily aspirin use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Based on the current literature, the biomarkers, which might predict aspirin treatment outcomes in AERD patients, were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results and conclusions<\/jats:title><jats:p>Patients with severe symptoms of chronic rhinosinusitis, type 2 asthma based on blood eosinophilia, non\u2010neutrophilic inflammatory phenotype based on sputum cells, as well as high plasma level of 15\u2010hydroxyeicosatetraenoic acid (15\u2010HETE) are potentially good responders to long term high\u2010dose aspirin therapy. Additionally, high expression of the hydroxyprostaglandin dehydrogenase gene, <jats:italic>HPGD<\/jats:italic> encoding prostaglandin\u2010degrading enzyme 15\u2010hydroxyprostaglandin dehydrogenase (15\u2010PGDH) and low expression of the proteoglycan 2 gene, <jats:italic>PRG2<\/jats:italic> encoding constituent of the eosinophil granule in sputum cells might serve as a predictor of good response to aspirin therapy. Variations in the expression of cysteinyl leukotriene receptor 1 in the airways could additionally influence the response to long\u2010term aspirin therapy. Arachidonic acid metabolites levels via the 5\u2010lipoxygenase as well as via the cyclooxygenase pathways in induced sputum supernatant do not change during high dose long\u2010term aspirin therapy and do not influence outcomes of aspirin treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clt2.12048","type":"journal-article","created":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T11:54:36Z","timestamp":1628855676000},"source":"Crossref","is-referenced-by-count":8,"title":["Biomarkers for predicting response to long\u2010term high dose aspirin therapy in aspirin\u2010exacerbated respiratory disease"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8994-0036","authenticated-orcid":false,"given":"Lucyna","family":"Mastalerz","sequence":"first","affiliation":[{"name":"2nd Department of Internal Medicine Jagiellonian University Medical College  Cracow 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