{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T08:29:06Z","timestamp":1778315346365,"version":"3.51.4"},"reference-count":7,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T00:00:00Z","timestamp":1627603200000},"content-version":"vor","delay-in-days":29,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp; Translational All"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We aimed to evaluate the effectiveness of different antibody therapies on nasal polyp symptoms in patients treated for severe asthma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective analysis of patients with severe asthma\u00a0and comorbid CRSwNP who were treated with anti\u2010IgE, anti\u2010IL\u20105\/R or anti\u2010IL\u20104R. CRSwNP symptom burden was evaluated before and after 6\u00a0months of therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty patients were included hereof treated with anti\u2010IgE: 9, anti\u2010IL\u20105\/R: 26 and anti\u2010IL\u20104R: 15 patients. At baseline median SNOT\u201020 was similar among groups (anti\u2010IgE: 55, anti\u2010IL\u20105\/R: 52 and anti\u2010IL\u20104R: 56, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.76), median visual analogue scale (VAS) for nasal symptoms was 4, 7 and 8 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.14) and VAS for total symptoms was higher in the anti\u2010IL\u20104R group (4, 5 and 8, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.002). After 6\u00a0months SNOT\u201020 improved significantly in all patient groups with median improvement of anti\u2010IgE: \u22128 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01), anti\u2010IL\u20105\/R: \u221213 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) and anti\u2010IL\u20104R: \u221218 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), with larger improvement in the anti\u2010IL\u20104R group than in anti\u2010IgE (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) and anti\u2010IL\u20105\/R (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) groups. VAS nasal symptoms improved by median anti\u2010IgE: 0 (n.s.), anti\u2010IL\u20105\/R: \u22121 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01) and anti\u2010IL\u20104R: \u22123 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), VAS total symptoms by anti\u2010IgE: \u22121 (n.s.), anti\u2010IL\u20105\/R: \u22122 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) and anti\u2010IL\u20104R: \u22122 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Treatment by all antibodies showed effectiveness in reducing symptoms of CRSwNP in patients with severe asthma, with the largest reduction observed in anti\u2010IL\u20104R\u2010treated patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clt2.12049","type":"journal-article","created":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T07:44:50Z","timestamp":1627631090000},"source":"Crossref","is-referenced-by-count":30,"title":["Real\u2010life effectiveness of biological therapies on symptoms in severe asthma with comorbid CRSwNP"],"prefix":"10.1002","volume":"11","author":[{"given":"Carlo","family":"M\u00fcmmler","sequence":"first","affiliation":[{"name":"Department of Medicine V University Hospital LMU Munich  Munich Germany"},{"name":"Comprehensive Pneumology Center (CPC\u2010M) LMU and Helmholtz Center Munich  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristin","family":"D\u00fcnzelmann","sequence":"additional","affiliation":[{"name":"Department of Medicine V University Hospital LMU Munich  Munich Germany"},{"name":"Comprehensive Pneumology Center (CPC\u2010M) LMU and Helmholtz Center Munich  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaus","family":"Kneidinger","sequence":"additional","affiliation":[{"name":"Department of Medicine V University Hospital LMU Munich  Munich Germany"},{"name":"Comprehensive Pneumology Center (CPC\u2010M) LMU and Helmholtz Center Munich  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michaela","family":"Barnikel","sequence":"additional","affiliation":[{"name":"Department of Medicine V University Hospital LMU Munich  Munich Germany"},{"name":"Comprehensive Pneumology Center (CPC\u2010M) LMU and Helmholtz Center Munich  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dieter","family":"Munker","sequence":"additional","affiliation":[{"name":"Department of Medicine V University Hospital LMU Munich  Munich Germany"},{"name":"Comprehensive Pneumology Center (CPC\u2010M) LMU and Helmholtz Center Munich  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moritz","family":"Gr\u00f6ger","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology University Hospital LMU Munich  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Canis","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology University Hospital LMU Munich  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Behr","sequence":"additional","affiliation":[{"name":"Department of Medicine V University Hospital LMU Munich  Munich Germany"},{"name":"Comprehensive Pneumology Center (CPC\u2010M) LMU and Helmholtz Center Munich  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Koch","sequence":"additional","affiliation":[{"name":"Abteilung f\u00fcr Lungenheilkunde Pyhrn\u2010Eisenwurzen Klinikum Steyr  Munich Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Haubner","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology University Hospital LMU Munich  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2914-8773","authenticated-orcid":false,"given":"Katrin","family":"Milger","sequence":"additional","affiliation":[{"name":"Department of Medicine V University Hospital LMU Munich  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,7,30]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1586\/ers.11.34"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31881-1"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.05.032"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(21)00097-7"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00202013"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-869285"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2005.0077.x"}],"container-title":["Clinical and Translational Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clt2.12049","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/clt2.12049","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clt2.12049","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T20:57:58Z","timestamp":1693342678000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clt2.12049"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":7,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1002\/clt2.12049"],"URL":"https:\/\/doi.org\/10.1002\/clt2.12049","archive":["Portico"],"relation":{},"ISSN":["2045-7022","2045-7022"],"issn-type":[{"value":"2045-7022","type":"print"},{"value":"2045-7022","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7]]},"article-number":"e12049"}}