{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:44:19Z","timestamp":1753868659654,"version":"3.41.2"},"reference-count":18,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T00:00:00Z","timestamp":1630022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp; Translational All"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>COVID\u201019 is a highly contagious respiratory disease caused by the SARS\u2010CoV\u20102 virus. Patients with severe disease have a high fatality rate and face a huge medical burden due to the need for invasive mechanical ventilation. Hypoxic respiratory failure is the major cause of death in these patients. There are currently no specific anti\u2010SARS\u2010CoV\u20102 drugs, and the effect of corticosteroids is still controversial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The clinical data of 102 COVID\u201019 patients, including 27 patients with severe disease, were analyzed. The serum levels of total IgE and anti\u2010SARS\u2010CoV\u20102 specific IgE were compared in healthy controls and COVID\u201019 patients, changes in the level of anti\u2010SARS\u2010CoV\u20102 specific IgE and clinical response to methylprednisolone (MP) treatment were analyzed, and the effect of high\u2010dose\/short\u2010term MP therapy for patients with critical illness and respiratory failure was determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>COVID\u201019 patients had elevated serum levels of anti\u2010SARS\u2010CoV\u20102 specific IgE, and patients with severe disease, especially critical illness, had even higher levels. Application of short\u2010term\/high\u2010dose MP significantly reduced the level of these IgE antibodies and also blocked the progression of hypoxic respiratory failure. Hypoxic respiratory failure in patients with COVID\u201019 is related to pulmonary hypersensitivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Hypersensitivity in the lungs is responsible for acute respiratory failure in COVID\u201019 patients. Application of high\u2010dose\/short\u2010term MP appears to be an effective life\u2010saving method for COVID\u201019 patients who have hypoxic respiratory failure.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clt2.12056","type":"journal-article","created":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T13:08:48Z","timestamp":1630069728000},"source":"Crossref","is-referenced-by-count":2,"title":["Hypersensitivity in the lungs is responsible for acute respiratory failure in COVID\u201019 patients: Case series of patients who received high\u2010dose\/short\u2010term methylprednisolone"],"prefix":"10.1002","volume":"11","author":[{"given":"Meizhu","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine (PCCM) The Fifth Affiliated Hospital of Sun Yat\u2010sen University  Zhuhai Guangdong Province 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