{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T22:41:52Z","timestamp":1782513712533,"version":"3.54.5"},"reference-count":34,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T00:00:00Z","timestamp":1634083200000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006120","name":"Ministry of the Environment","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006120","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp; Translational All"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The effects of early\u2010life exposure to house dust mite allergen and endotoxin on the development of asthma are unclear in the literature. We investigated the association of early\u2010life exposure (0\u201336\u00a0months old) to house dust mite allergen and endotoxin with asthma incidence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this novel, large\u2010scale, nationwide birth cohort study, 5017 participants were randomly selected from those who met the eligibility criteria. House dust was vacuum\u2010sampled from the children's mattresses within homes and assayed for the presence of dust mite allergen (Der 1) and endotoxin. The participants were classified into four quartiles (Q1\u2013Q4) according to exposure levels. We defined the incidence of asthma and wheezing using questionnaires at 12, 24, and 36\u00a0months old. Odds ratios (ORs) of the incidence of asthma and wheezing by age in Der 1 and endotoxin exposure level were estimated using logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cumulative incidence rates of asthma and wheezing during 0\u201336\u00a0months were 10.4% and 38.1%, respectively. Significant ORs were observed in asthma onset\u00a0during 12\u201324\u00a0months old, asthma onset during 24\u201336\u00a0months old, and wheezing onset during 0\u201312\u00a0months old in the Q4 Der 1 group. In the Q4 endotoxin group, significant positive associations between endotoxin exposure and asthma (OR 2.00, 95% confidence interval [CI]: 1.03\u20133.85) and wheezing (OR 1.78, 95% CI: 1.01\u20133.12) onset during 24\u201336\u00a0months old were found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results indicated that high levels of early\u2010life exposure to Der 1 and endotoxin in mattresses may be involved in the development of asthma.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clt2.12071","type":"journal-article","created":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T06:18:28Z","timestamp":1634278708000},"source":"Crossref","is-referenced-by-count":14,"title":["Effects of early\u2010life exposure to dust mite allergen and endotoxin on the development of asthma and wheezing: The Japan Environment and Children's Study"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5622-6338","authenticated-orcid":false,"given":"Hideki","family":"Hasunuma","sequence":"first","affiliation":[{"name":"Department of Public Health Hyogo College of Medicine  Nishinomiya Japan"},{"name":"Hyogo Regional Centre for the Japan Environment and Children's Study  Nishinomiya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiko","family":"Yoda","sequence":"additional","affiliation":[{"name":"Department of Public Health Hyogo College of Medicine  Nishinomiya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narumi","family":"Tokuda","sequence":"additional","affiliation":[{"name":"Hyogo Regional Centre for the Japan Environment and Children's Study  Nishinomiya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoko","family":"Taniguchi","sequence":"additional","affiliation":[{"name":"Hyogo Regional Centre for the Japan 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