{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T22:22:38Z","timestamp":1780525358545,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,1,8]],"date-time":"2022-01-08T00:00:00Z","timestamp":1641600000000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp; Translational All"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>During the COVID\u201019 pandemic focus has been on polyethylene glycol (PEG) and polysorbate as these excipients are constituents in the first vaccines and possible elicitors of allergic reactions to the vaccines. We aimed to evaluate the possibility of vaccinating patients with PEG and\/or polysorbate allergy against COVID\u201019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010five patients with a history of an allergic reaction to drugs, vaccines and mouth hygiene products containing PEG or polysorbate and sensitization (skin test or in vitro test) or a positive challenge were included. We re\u2010evaluated 19 of 21 patients diagnosed before 2021 and four new patients by skin prick tests (SPT) and Basophil Histamine Release (BaHR) for PEGs, polysorbates and approved COVID\u201019 vaccines as well as measurement of specific IgE (PEG 2000, 10,000). Patients were offered vaccination based on decision points from the primary diagnosis and re\u2010evaluation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Most common primary elicitors were depot\u2010steroids and laxatives. Most patients had experienced more than one reaction. SPT was superior to BaHR test although many SPTs became negative over time. After careful re\u2010evaluation three patients were successfully vaccinated with the Pfizer\/BioNTech vaccine. Three were vaccinated before referral. Eleven were offered the Johnson\u2010Johnson vaccine; four were vaccinated successfully, seven abstained. Six patients could not be vaccinated with PEG or polysorbate containing vaccines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Hypersensitivity to excipients in COVID\u201019 vaccines constitutes a risk to patients with allergy to PEG or polysorbates. After diagnostic evaluation, a safe COVID\u201019 vaccine could be offered to most patients, the remainders will await new vaccines containing different excipients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clt2.12111","type":"journal-article","created":{"date-parts":[[2022,1,8]],"date-time":"2022-01-08T13:01:24Z","timestamp":1641646884000},"source":"Crossref","is-referenced-by-count":35,"title":["Allergy to polyethylene glycol and polysorbates in a patient cohort: Diagnostic work\u2010up and decision points for vaccination during the COVID\u201019 pandemic"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8710-0829","authenticated-orcid":false,"given":"Charlotte G.","family":"Mortz","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy Centre, Odense Research Centre for Anaphylaxis (ORCA), Odense University Hospital University of Southern Denmark  Odense C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8043-0718","authenticated-orcid":false,"given":"Henrik F.","family":"Kjaer","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Centre, Odense Research Centre for Anaphylaxis (ORCA), Odense University Hospital University of Southern Denmark  Odense C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2761-8153","authenticated-orcid":false,"given":"Trine H.","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Centre, Odense Research Centre for Anaphylaxis (ORCA), Odense University Hospital University of Southern Denmark  Odense C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8042-1881","authenticated-orcid":false,"given":"Helene M.","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Centre, Odense Research Centre for Anaphylaxis (ORCA), Odense University Hospital University of Southern Denmark  Odense C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7777-4501","authenticated-orcid":false,"given":"Lene Heise","family":"Garvey","sequence":"additional","affiliation":[{"name":"Allergy Clinic Copenhagen University Hospital at Gentofte  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8940-038X","authenticated-orcid":false,"given":"Carsten","family":"Bindslev\u2010Jensen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Centre, Odense Research Centre for Anaphylaxis (ORCA), Odense University Hospital University of Southern Denmark  Odense C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,8]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"Coronavirus disease (COVID\u20102019) situation reports. 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