{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T04:18:18Z","timestamp":1770956298099,"version":"3.50.1"},"reference-count":11,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,8,20]],"date-time":"2022-08-20T00:00:00Z","timestamp":1660953600000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp; Translational All"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Asthma is a heterogeneous respiratory disease that encompasses different inflammatory and functional endophenotypes. Many non\u2010invasive biomarkers has been investigated to its pathobiology. Heany et\u00a0al proposed a clinical algorithm that classifies severe asthmatic patients into likely\u2010eosinophilic phenotypes, based on accessible biomarkers: PBE, current treatment, FeNO, presence of\u00a0nasal polyps (NP) and age of onset.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We assessed the concordance between the algorithm proposed by Heany et\u00a0al. with sputum examination, the gold standard, in 145 asthmatic patients of the MEGA cohort with varying grades of severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No correlation was found between both classifications 0.025 (CI\u00a0=\u00a00.013\u20130.037). Moreover, no relationship was found between sputum eosinophilia and peripheral blood eosinophilia count in the total studied population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion and Conclusion<\/jats:title><jats:p>In conclusion, our results suggest that grouping the biomarkers proposed by Heany et\u00a0al. are insufficient to diagnose eosinophilic phenotypes in asthmatic patients. Sputum analysis remains the gold standard to assess airway inflammation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clt2.12182","type":"journal-article","created":{"date-parts":[[2022,8,20]],"date-time":"2022-08-20T08:05:39Z","timestamp":1660982739000},"source":"Crossref","is-referenced-by-count":5,"title":["How reliably can algorithms identify eosinophilic asthma phenotypes using non\u2010invasive biomarkers?"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2765-3581","authenticated-orcid":false,"given":"Diana","family":"Betancor","sequence":"first","affiliation":[{"name":"Servicio de Alergolog\u00eda Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Mar\u00eda","family":"Olaguibel","sequence":"additional","affiliation":[{"name":"Servicio de Alergolog\u00eda Hospital Universitario de Navarra  Pamplona Navarra Spain"},{"name":"CIBER de Enfermedades Respiratorias (CIBERES)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Manuel","family":"Rodrigo\u2010Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"CIBER de Enfermedades Respiratorias (CIBERES)  Madrid Spain"},{"name":"Servicio de Inmunolog\u00eda Instituto de Investigaci\u00f3n Sanitaria Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ebymar","family":"Arismendi","sequence":"additional","affiliation":[{"name":"CIBER de Enfermedades Respiratorias (CIBERES)  Madrid Spain"},{"name":"Allergy Unit &amp; Severe Asthma Unit, Pneumonology and Allergy Department Hospital Cl\u00ednic IDIBAPS Universitat de Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pilar","family":"Barranco","sequence":"additional","affiliation":[{"name":"CIBER de Enfermedades Respiratorias (CIBERES)  Madrid Spain"},{"name":"Servicio de Alergia Hospital Universitario La Paz IdiPAZ  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blanca","family":"Barroso","sequence":"additional","affiliation":[{"name":"Servicio de Alergolog\u00eda Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina","family":"Bobolea","sequence":"additional","affiliation":[{"name":"CIBER de Enfermedades Respiratorias (CIBERES)  Madrid Spain"},{"name":"Allergy Unit &amp; Severe Asthma Unit, Pneumonology and Allergy Department Hospital Cl\u00ednic IDIBAPS Universitat de Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blanca","family":"C\u00e1rdaba","sequence":"additional","affiliation":[{"name":"CIBER de Enfermedades Respiratorias (CIBERES)  Madrid Spain"},{"name":"Servicio de Inmunolog\u00eda Instituto de Investigaci\u00f3n Sanitaria Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Jes\u00fas","family":"Cruz","sequence":"additional","affiliation":[{"name":"CIBER de Enfermedades Respiratorias (CIBERES)  Madrid Spain"},{"name":"Departamento de Biolog\u00eda Celular, Fisiolog\u00eda e Inmunolog\u00eda Universitat Aut\u00f3noma de Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Curto","sequence":"additional","affiliation":[{"name":"CIBER de Enfermedades Respiratorias (CIBERES)  Madrid Spain"},{"name":"Departamento de Medicina Respiratoria Hospital de la Santa Creu i Sant Pau Instituto de Investigaci\u00f3n Biom\u00e9dica Sant Pau (IIB Sant Pau) Universidad Aut\u00f3noma de Barcelona. Departamento de Medicina  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"Del Pozo","sequence":"additional","affiliation":[{"name":"CIBER de Enfermedades Respiratorias (CIBERES)  Madrid Spain"},{"name":"Servicio de Inmunolog\u00eda Instituto de Investigaci\u00f3n Sanitaria Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5847-4784","authenticated-orcid":false,"given":"Francisco\u2010Javier","family":"Gonz\u00e1lez\u2010Barcala","sequence":"additional","affiliation":[{"name":"Servicio de Neumolog\u00eda Complejo Hospitalario Universitario de Santiago  Santiago de Compostela La Coru\u00f1a Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Mart\u00ednez\u2010Rivera","sequence":"additional","affiliation":[{"name":"CIBER de Enfermedades Respiratorias (CIBERES)  Madrid Spain"},{"name":"Servicio de Neumolog\u00eda Hospital Germans Trias i Pujol Institut d\u2019Investigaci\u00f3 Germans Trias i Pujol Universitat Aut\u00f2noma de Barcelona  Badalona, Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3463-5007","authenticated-orcid":false,"given":"Joaquim","family":"Mullol","sequence":"additional","affiliation":[{"name":"CIBER de Enfermedades Respiratorias (CIBERES)  Madrid Spain"},{"name":"Rhinology Unit &amp; Smell Clinic ENT Department Clinical and Experimental Respiratory Immunoallergy (IDIBAPS) Universitat de Barcelona  Barcelona Catalonia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"CIBER de Enfermedades Respiratorias (CIBERES)  Madrid Spain"},{"name":"Servicio de Neumolog\u00eda Hospital Vall d\u2019Hebron  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cesar","family":"Picado","sequence":"additional","affiliation":[{"name":"Allergy Unit &amp; Severe Asthma Unit, Pneumonology and Allergy Department Hospital Cl\u00ednic IDIBAPS Universitat de Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicente","family":"Plaza","sequence":"additional","affiliation":[{"name":"CIBER de Enfermedades Respiratorias (CIBERES)  Madrid Spain"},{"name":"Departamento de Medicina Respiratoria Hospital de la Santa Creu i Sant Pau Instituto de Investigaci\u00f3n Biom\u00e9dica Sant Pau (IIB Sant Pau) Universidad Aut\u00f3noma de Barcelona. 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