{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:08:19Z","timestamp":1791922099226,"version":"4.3.4"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T00:00:00Z","timestamp":1658361600000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp; Translational All"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Anaphylaxis has increased over the last two\u00a0decades in Europe, reaching an estimated prevalence of 0.3% and an incidence of 1.5\u20137.9 per 100,000 person\u2010years. Allergic multimorbidity is associated with asthma severity, yet its role in anaphylaxis is not fully understood. Our aim was to study association between allergic multimorbidity and anaphylaxis in adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used population\u2010based data from the Finnish Allergy Barometer Study (<jats:italic>n<\/jats:italic>\u00a0=\u00a02070, age range: 5\u201375). Food allergy (FA), atopic dermatitis (AD), allergic rhinitis (AR) and allergic conjunctivitis (AC), were defined from a self\u2010completed questionnaire. A logistic regression adjusted on potential confounders (sex, age, smoking status) was applied to estimate the anaphylaxis risk associated with allergic multimorbidity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>1319 adults with at least one allergic disease (FA, AD, AR, AC) with\/without asthma (AS) were included. Of these, 164 had self\u2010reported anaphylaxis [mean (SD, min\u2010max) 54 (14, 22\u201375) years, 17% men]. AS, FA, AR, AC, or AD were reported by 86.0%, 62.2%, 82.3%, 43.3%, and 53.7% of subjects with anaphylaxis and respectively by 67.8%, 29.5%, 86.2%, 29.4%, and 34.4% of subjects without anaphylaxis. Compared with subjects exhibiting only one allergic disease, the risk of anaphylaxis increased with the number of allergic diseases; adjusted odds ratios (OR) [CI95%] for two, three, four and five coinciding allergic diseases were 1.80 [0.79\u20134.12], 3.35 [1.47\u20137.66], 7.50 [3.25\u201317.32], and 13.5 [5.12\u201333.09], respectively. The highest risk of anaphylaxis (6.47 [4.33\u20139.92]) was associated with FA\u00a0+\u00a0AS or their various variations with AR\/AC\/AD embodied, when compared with AR, AC, and AS separately or their combinations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Anaphylaxis was positively associated with the number of allergic diseases a subject exhibited and with subgroups including FA and\/or AS. The results can be applied when estimating the risk of anaphylaxis for individual patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clt2.12184","type":"journal-article","created":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T11:03:58Z","timestamp":1658401438000},"source":"Crossref","is-referenced-by-count":6,"title":["Allergic multimorbidity is associated with self\u2010reported anaphylaxis in adults\u2014A cross\u2010sectional questionnaire study"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5675-2987","authenticated-orcid":false,"given":"Tuuli","family":"Thomander","sequence":"first","affiliation":[{"name":"Doctoral Programme in Clinical Research University of Helsinki  Helsinki Finland"},{"name":"Department of Allergology Skin and Allergy Hospital Helsinki University Hospital and University of Helsinki  Helsinki 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